目的 探討帕利哌酮緩釋片與奧氮平對首發(fā)精神分裂癥患者的療效及社會功能的影響.方法 2012年1月至2014年1月北京市房山區(qū)精神衛(wèi)生保健院收治的首發(fā)精神分裂癥患者100例,隨機(jī)分為治療組(帕利哌酮緩釋片)與對照組(奧氮平),每組50例,用藥12周后以陽性和陰性癥狀量表(PANSS)和社會功能量表(PSP)評價(jià)療效.結(jié)果 治療組治療后的總有效率達(dá)90%,顯著高于對照組;治療后第4周末PANSS總分、陽性癥狀均顯著低于對照組;治療后第12周末PANSS總分、陽性癥狀、陰性癥狀、思維混亂各因子評分均顯著低于對照組(P <0.05).治療后第2、4、12周末均治療組PSP評分顯著高于對照組(P <0.05).結(jié)論 帕利哌酮緩釋片與奧氮平治療首發(fā)精神分裂癥均具有較好的療效,但帕利哌酮較奧氮平可以明顯改善患者的社會功能.

Objective To investigate the effect of Paliperidone Extended-Release Tablets and olanzapine on efficacy and social function in treatment of schizophrenia patients. Methods One hundred cases of schizophrenia patients from January 2012 to January 2014 were randomly divided into observation group (Paliperidone Extended-Release Tablets) and control group (Olanzapine), 50 cases in each group, treatment for 12 weeks, and the curative effect was compared by PANSS score and PSP score. Results The total effective rate of observation group was 90%, higher than that of the control group(P <0.05). After 4 weeks treatment, the PANSS score and positive symptom of observation group were significantly lower than those of the control group. After 12 weeks, the PANSS score, positive symptoms, negative symptoms, and confusion of each factor score of the observation group decreased significantly compared with those of the control group (P <0.05). The PSP score in the observation group after 2, 4, and 12 weeks treatment were significantly higher than those in the control group (P <0.05). Conclusion Paliperidone Extended-Release Tablets and olanzapine in the treatment of first-episode schizophrenia have better efficacy, but Paley cefoperazone has better effect than olanzapine in improving symptoms of patients, can significantly improve the social function of patients, and is worthy of promotion and application.