目的 探究寧泌泰膠囊對盆腔炎病癥的改善作用。方法 選用大鼠大腸桿菌感染性盆腔炎模型,苯酚膠漿引起大鼠化學(xué)性盆腔炎模型,用婦科千金片(1.0 g/kg)及寧泌泰膠囊高、中、低劑量(2.0、1.0、0.5 g/kg)連續(xù)ig 7 d,每天2 次。以動物體質(zhì)量變化、白細胞計數(shù)、病理學(xué)檢查評價寧泌泰膠囊對盆腔炎的治療作用。結(jié)果 寧泌泰膠囊3 個劑量組對大腸桿菌引起的感染性盆腔炎大鼠子宮肉眼可見的炎性癥狀有一定的改善作用,可不同程度地抑制炎癥引起的血中白細胞的數(shù)量升高,并且能改善炎癥引起的體質(zhì)量下降。寧泌泰膠囊高、中(2.0、1.0 g/kg)劑量組可顯著減輕子宮的質(zhì)量,提示抑制炎癥引起的腫脹。子宮組織病理學(xué)檢查結(jié)果表明,寧泌泰膠囊可改善大腸桿菌感染引起的大鼠子宮組織學(xué)病變,且有一定的劑量相關(guān)性。對于苯酚膠漿引起的大鼠盆腔炎,寧泌泰膠囊3 個劑量組均能改善炎癥引起的體質(zhì)量下降。寧泌泰膠囊高劑量組(2.0g/kg)可顯著抑制炎癥引起的血中白細胞的數(shù)量升高,并且可顯著減輕子宮的質(zhì)量,提示抑制炎癥引起的腫脹。子宮組織病理學(xué)檢查結(jié)果表明,寧泌泰膠囊可改善苯酚膠漿引起的大鼠子宮組織學(xué)病變,且有一定的劑量相關(guān)性。結(jié)論 寧泌泰膠囊對于化學(xué)性和細菌性等多種因素引起的盆腔炎動物模型的相關(guān)癥狀具有明顯的改善作用。

Objective To investigate the therapeutic effect of Ningmitai Capsule for pelvic inflammation. Methods Using pelvic inflammation model induced by coliform and phenol in rats, the model mice were ig administrated with Qianjin Formula (1 g/kg) and Ningmitai Capsule (2, 1, and 0.5 g/kg). All rats and rabbits were fed for 7 d. The body weight, amount of WBC, histological lesions were determined to evaluate the therapeutic effect of Ningmitai Capsule for uterus. Results Pelvic inflammation model induced by coliform in rats could significantly reduce the number of leukocytes in blood and improve weight loss caused by inflammation. The histopathology results showed that Ningmitai Capsule could improve histological lesions of pelvic inflammation. There are certain contacts of efficacy and dose. In addition, pelvic inflammation induced by phenol in rats, Ningmitai Capsule (2.0 g/kg) can significantly reduce the number of leukocytes in the blood. The histopathology results showed that Ningmitai Capsule could improve histological lesions in vagin. Conclusion Ningmitai Capsules have significant effects on symptoms of pelvic inflammation induced by a variety of bacterial and chemical factors.