肺癌發(fā)病率和死亡率居全球惡性腫瘤首位,作為治療主導方向的化療,藥物推陳出新,方案不斷優(yōu)化,療效卻已達“平臺期”,究其原因,肺癌細胞的多藥耐藥(MDR)不容忽視。尋找肺癌化療耐藥逆轉劑,逆轉MDR 是腫瘤領域的研究熱點。中藥活性廣泛而顯著,高效小毒,多靶點逆轉MDR,臨床藥效逐步得到肯定,但明確的逆轉機制尚待研究。

The incidence and mortality of lung cancer are in the first place of all cancers in the world. As the leading treatment, chemotherapy drugs continue to be updated, and the treatment plan is optimized, but the curative effect has reached the “platform stage”. To investigate the reason, the multi drug resistance (MDR) of lung cancer cells can not be ignored. MDR has become a hot research topic in the field of lung cancer for discovery of drug resistance reversal agents. Chinese materia medica (CMM) is active in a wide range, with high efficiency, low toxicity, and multiple targets, and can reverse MDR. The clinical efficacy of CMM is gradually confirmed, and its reversal mechanism is still to be studied.

天津市應用基礎及前沿技術研究計劃(青年基金項目)(12JCQNJC07500);天津市高等學?？萍及l(fā)展基金計劃項目(20110223)