熊果酸和齊墩果酸廣泛存在于蔬菜、水果和中草藥里,并被廣泛研究。二者不僅同屬五環(huán)三萜酸類化合物,又是同分異構(gòu)體,藥理作用幾乎相同,都具有抗炎、抗變態(tài)反應、抗微生物、降血糖、調(diào)血脂、減肥、抗動脈粥樣硬化、抗骨質(zhì)疏松、保肝和免疫調(diào)節(jié)以及抗焦慮、抗抑郁、改善學習記憶等作用。熊果酸和齊墩果酸還具有廣譜抗腫瘤作用,包括呼吸系腫瘤、消化系腫瘤、性器官腫瘤、皮膚癌和白血病等。綜述熊果酸和齊墩果酸抗腦瘤作用及其機制的研究進展,為新藥研發(fā)提供依據(jù)。

Ursolic acid and oleanolic acid, both belonging to pentacyclic triterpene carboxylic acid, exit in many plants (vegetable, fruit, and herb), are extensively researched, and are isomers yet. Their pharmacologic effects are fully alike. Ursolic acid and oleanolic acid have the pharmacologic effects of anti-inflammation, anti-allergy, anti-microbe, hypoglycemia, lipidemic regulation, antiobesity, antiatherosclerosis, anti-osteoporosis, hepatoprotection, immunomodulation, anti-anxiety, antidepression, and improvement of study and menory. Ursolic acid and oleanolic acid yet have broad antitumor effects, inclusive of leukemia, skin cancer, sexual organ carcinoma, digestive systemic tumor, and respiratory systemic tumor. In this paper, research advances in the effects and mechanisms of ursolic acid and oleanolic acid against brain neoplasms are reviewed.