積雪草總苷是積雪草的主要活性成分,其中的單體成分包括積雪草苷、羥基積雪草苷和積雪草酸等,在臨床上主要用于治療皮膚損傷,促進(jìn)創(chuàng)面愈合以及瘢痕修復(fù)等。近年來發(fā)現(xiàn)積雪草苷類化學(xué)成分對(duì)神經(jīng)系統(tǒng)也存在著多種藥理活性,如抗抑郁、抗癡呆、對(duì)脊髓損傷以及脊髓神經(jīng)細(xì)胞變性的保護(hù)、對(duì)抗腦缺血損傷以及鎮(zhèn)痛、抗驚厥等。綜述積雪草苷類化學(xué)成分對(duì)神經(jīng)系統(tǒng)的藥理作用研究進(jìn)展,希望為該類化合物治療神經(jīng)系統(tǒng)疾病的研究與應(yīng)用及新藥開發(fā)提供理論依據(jù)。

Total triterpenes are the main active ingredients in Centella asiatica, in which the main monomer components are asiaticoside, madecassoside, asiatic acid, etc. The clinical treatment is mainly used in the treatment of skin injury, wound healing, scar repair, etc. In recent years, it has been found that total triterpenes of C. asiatica and its main monomer components have many pharmacological activities on the nervous system, such as anti-depression, anti-dementia, protection of spinal cord injury and spinal cord nerve cell degeneration, anti-brain ischemia injury, analgesia, anti-seizure, etc. This paper gives an overview of research progress of the pharmacological effects of the C. asiatica compound on the nervous system, hoping to provide a theoretical basis for the research and application of this compound in the treatment of nervous system diseases and new drug development.