多發(fā)性硬化是一種免疫介導(dǎo)的中樞神經(jīng)系統(tǒng)炎癥性脫髓鞘性疾病,目前尚無治愈方法。近年來利用甲狀腺激素對多發(fā)性硬化的動物模型進行治療,發(fā)現(xiàn)甲狀腺激素可促進髓鞘再生,對軸索和神經(jīng)元有保護作用,這就對治療多發(fā)性硬化癥開辟了一條新思路。綜述了利用甲狀腺激素在實驗性自身免疫性腦脊髓炎(EAE)模型,雙環(huán)己銅草酰二腙(CPZ)誘導(dǎo)脫髓鞘模型等動物模型中的研究進展,以期為臨床應(yīng)用以及新藥研發(fā)提供參考。

Multiple sclerosis is an immune-mediated inflammatory demyelinating disease of central nervous system. There is no cure method. In the study of the treatment of multiple sclerosis, demyelinating animal model has played an important role. At present, the study found in animal models of multiple sclerosis, thyroid hormone (TH) can promote the remyelination and protect the axon and neurons. Those studies open the possibility to future investigation on the therapy of MS. This article will take a rewiew for relative researches in past years, to provide some reference for clinical application.