目的 分析甘草鋅顆粒聯(lián)合酪酸梭菌活菌散治療小兒遷延性腹瀉的臨床療效,為小兒遷延性腹瀉的治療提供借鑒。方法 以入渭南市中心醫(yī)院治療的遷延性腹瀉的患兒128例為研究對象,將患兒隨機(jī)分為觀察組和對照組,每組各64例。兩組腹瀉時給予去除病因、糾正脫水、電解質(zhì)及酸堿平衡紊亂,對癥支持治療,在此基礎(chǔ)上對照組口服酪酸梭菌活菌散,治療組在對照組的基礎(chǔ)上聯(lián)合甘草鋅顆粒,療程為10 d,觀察大便次數(shù)及性狀等療效性。結(jié)果 第5天,觀察組與對照組患兒遷延性腹瀉的總有效率分別為48.44%和31.38%,經(jīng)秩和檢驗(yàn),差異有顯著性(P<0.05)。第10天,總有效率分別為93.75%和92.19%,經(jīng)秩和檢驗(yàn),差異無顯著性。觀察組和對照組組內(nèi)總有效率比較,差異有顯著性(P<0.05)。觀察組腹痛、腹脹、惡心、嘔吐、食欲減退、飲食減少緩解時間與對照組相比,均短于對照組,經(jīng)比較,差異有顯著性(P<0.05)。治療前兩組患兒CD₄⁺、CD₈⁺細(xì)胞分?jǐn)?shù)及其細(xì)胞比值比較,差異無顯著性;治療后,CD₄⁺、CD₈⁺細(xì)胞分?jǐn)?shù)及其比值比較,觀察組患兒CD₄⁺及細(xì)胞比值明顯高于對照組,觀察組患兒CD₈⁺及細(xì)胞比值明顯低于對照組,差異有顯著性(P<0.05)。結(jié)論 甘草鋅顆粒聯(lián)合酪酸梭菌活菌散治療遷延性腹瀉可改善患兒營養(yǎng)狀況并糾正腸道菌群,縮短病程,提高機(jī)體免疫力。

Objective To analyze the clinical effects of licorzine granules with clostridium butyricum powder in treatment of protracted diarrhea in infants, in order to provide guidance for treatment of protracted diarrhea in infants. Methods Infants with protracted diarrhea were selected and randomly divided into observation group and control group. The treatment for both groups included removing the causes, correcting dehydration and the electrolyte disorder and symptomatic relief and supportive treatment. Clostridium butyricum powder was given to the infants of control group, and licorizine granules combined with clostridium butyricum powder was given to the infants of observation group. The treatment was lasting for 10 d with the observation indexes such as number and shape of defecation. Results Infants (128 cases) were in this research, with 64 cases in each group. The total effective rates of observation group and control group in day 5 were 48.44% and 31.38%, and the difference was statistically significant (P < 0.05). The total effective rates of observation group and control group in day 10 were 93.75% and 92.19%, and the difference was no statistically significant (P > 0.05). The effective rate in intra-group comparison was statistically significant (P < 0.05). The relief time of stomachache, bloating, nausea, loss of appetite and decrease of diet in observation group was much shorter than that in the control group with statistically significance (P < 0.05). Before treatment, the percentage and ratio of CD₄⁺ cells and CD₈⁺ cells had no statistically significance in both groups (P > 0.05). After treatment, the percentage and ration of CD₄⁺ cells and CD₈⁺ cells in observation group was higher than control group with statistically significance (P < 0.05). Conclusion Zinc agent with clostridium butyricum powder in treatment of protracted diarrhea in infants has good effect, which can improve nutrition outcomes, correct intestinal flora, shorten the length of the disease and enhance the body immunity.