目的 考察吉非替尼(GFB)脂質(zhì)體對(duì)S180荷瘤小鼠生存時(shí)間及生命質(zhì)量的影響。方法 30只小鼠制備S180荷瘤模型,隨機(jī)分為5組:模型組,GFB低、高劑量溶液(GFB-S-20、GFB-S-40)組,GFB低、高劑量脂質(zhì)體(GFB-L-20、GFB-L-40)組,低、高劑量為20、40 mg/kg。觀察荷瘤小鼠的生存時(shí)間、體質(zhì)量和腫瘤體積的增長(zhǎng)情況,并以為自主活動(dòng)次數(shù)為指標(biāo),評(píng)價(jià)小鼠的生命質(zhì)量。結(jié)果 與模型組比較,GFB組的生存時(shí)間明顯延長(zhǎng)(P<0.05、0.01),GFB-L-40組生存時(shí)間顯著長(zhǎng)于GFB-S-40組(P<0.05);模型組小鼠體質(zhì)量增長(zhǎng)最快;腫瘤生長(zhǎng)速度大小順序?yàn)?模型組> GFB-S-20組> GFB-S-40組> GFB-L-20組> GFB-L-40組;GFB顯著改善荷瘤小鼠自主活動(dòng)次數(shù)下降,相同劑量的溶液和脂質(zhì)體組之間存在顯著性差異(P<0.05)。結(jié)論 GFB脂質(zhì)體明顯延長(zhǎng)了S180荷瘤小鼠的生存時(shí)間,提高了生命質(zhì)量,效果優(yōu)于溶液組。

Objective To investigate the effects of gefitinib (GFB) liposomes on survival and quality of life of mice bearing S180 tumor. Methods The animal model bearing S180 tumor was established in 30 mice. The mice were randomly divided into five groups:model group, low-, high-dose GFB (GFB-S-20, GFB-S-40) groups, and low-, high-dose GFB liposomes (GFB-L-20, GFB-L-40) groups, and the administration of GFB solutions and GFB liposomes were 20 and 40 mg/kg. The growth and survival of mice bearing S180 tumor were observed for statistical analysis. The number of autonomic activity was used as indiactor to evaluate the quality of life of S180 tumor-bearing mice. Results Compared with model group, the survival time of the mice in GFB group was significantly longer (P<0.05, 0.01), the survival time of GFB-L-40 group was significantly longer than that of GFB-S-40 group (P<0.05), and body weight growth of model group was the fastest; The order of tumor growth speed was as follows:model group > GFB-S-20 group > GFB-S-40 group > GFB-L-20 group > GFB-L-40 group; GFB significantly improved the number decreasing of autonomic activities of tumor bearing mice, and there was significant difference between the same dose of solution and liposome group (P<0.05). Conclusions GFB liposomes could prolong the survival time and improve the quality of life obviously in S180 bearing mice, which is better than GFB solution.