目的 考察吉非替尼(GFB)脂質體對S180荷瘤小鼠生存時間及生命質量的影響。方法 30只小鼠制備S180荷瘤模型,隨機分為5組:模型組,GFB低、高劑量溶液(GFB-S-20、GFB-S-40)組,GFB低、高劑量脂質體(GFB-L-20、GFB-L-40)組,低、高劑量為20、40 mg/kg。觀察荷瘤小鼠的生存時間、體質量和腫瘤體積的增長情況,并以為自主活動次數為指標,評價小鼠的生命質量。結果 與模型組比較,GFB組的生存時間明顯延長(P<0.05、0.01),GFB-L-40組生存時間顯著長于GFB-S-40組(P<0.05);模型組小鼠體質量增長最快;腫瘤生長速度大小順序為:模型組> GFB-S-20組> GFB-S-40組> GFB-L-20組> GFB-L-40組;GFB顯著改善荷瘤小鼠自主活動次數下降,相同劑量的溶液和脂質體組之間存在顯著性差異(P<0.05)。結論 GFB脂質體明顯延長了S180荷瘤小鼠的生存時間,提高了生命質量,效果優(yōu)于溶液組。

Objective To investigate the effects of gefitinib (GFB) liposomes on survival and quality of life of mice bearing S180 tumor. Methods The animal model bearing S180 tumor was established in 30 mice. The mice were randomly divided into five groups:model group, low-, high-dose GFB (GFB-S-20, GFB-S-40) groups, and low-, high-dose GFB liposomes (GFB-L-20, GFB-L-40) groups, and the administration of GFB solutions and GFB liposomes were 20 and 40 mg/kg. The growth and survival of mice bearing S180 tumor were observed for statistical analysis. The number of autonomic activity was used as indiactor to evaluate the quality of life of S180 tumor-bearing mice. Results Compared with model group, the survival time of the mice in GFB group was significantly longer (P<0.05, 0.01), the survival time of GFB-L-40 group was significantly longer than that of GFB-S-40 group (P<0.05), and body weight growth of model group was the fastest; The order of tumor growth speed was as follows:model group > GFB-S-20 group > GFB-S-40 group > GFB-L-20 group > GFB-L-40 group; GFB significantly improved the number decreasing of autonomic activities of tumor bearing mice, and there was significant difference between the same dose of solution and liposome group (P<0.05). Conclusions GFB liposomes could prolong the survival time and improve the quality of life obviously in S180 bearing mice, which is better than GFB solution.