目的 研究應(yīng)用槐杞黃顆粒治療呼吸道合胞病毒(RSV)毛細(xì)支氣管炎患兒的臨床療效及對(duì)患兒免疫功能的調(diào)節(jié)作用。方法 將大連大學(xué)附屬中山醫(yī)院兒科收治的73例RSV毛細(xì)支氣管炎患兒采用隨機(jī)數(shù)字表法分為研究組36例和對(duì)照組37例,兩組患兒均給予化痰、止咳、平喘、抗感染治療,研究組患兒給予槐杞黃顆粒治療,比較兩組患兒治療1個(gè)月后的臨床療效、免疫水平指標(biāo)的變化情況。結(jié)果 研究組的咳嗽時(shí)間(5.3±1.8)d、氣促時(shí)間(2.7±1.4)d、肺部哮鳴音(4.9±1.6)d、肺部啰音(5.2±1.7)d、住院時(shí)間(6.8±1.7)d均顯著低于對(duì)照組患兒,且差異均具有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療前研究組和對(duì)照組的血清免疫球蛋白E(IgE)、免疫球蛋白-M(IgM)、免疫球蛋白-A(IgA)、免疫球蛋白-G(IgG)、γ-干擾素(INF-γ)、白細(xì)胞介素-4(IL-4)檢出值差異不具有統(tǒng)計(jì)學(xué)意義,治療后1個(gè)月復(fù)查,兩組患兒的IgE、IgA、INF-γ、IL-4檢出值均較治療前好轉(zhuǎn)且差異均具有統(tǒng)計(jì)學(xué)意義(P<0.05);研究組的IgE、IL-4檢出值較對(duì)照組顯著降低,IgA、INF-γ檢出值較對(duì)照組顯著升高,且差異均具有統(tǒng)計(jì)學(xué)意義(P<0.05)。研究組的治療顯效率為86.11%,顯著高于對(duì)照組患兒的62.16%,且差異均具有統(tǒng)計(jì)學(xué)意義(P<0.05);研究組治療后的有效率97.22%高于對(duì)照組患兒的91.89%,但差異不具有統(tǒng)計(jì)學(xué)意義。結(jié)論 槐杞黃顆粒對(duì)RSV毛細(xì)支氣管炎患兒具有調(diào)節(jié)體液免疫的功能,同時(shí)可以促進(jìn)患兒臨床癥狀的緩解,有利于提高治療效果。

Objective Research on the clinical curative effect of Huaiqihuang Granule in the treatment of respiratory tract virus (RSV) bronchiolitis and regulative effect on immune function of children. Methods Totally 73 cases of RSV bronchiolitis from department of pediatrics of Zhongshan Hospital affiliated to Dalian University were randomly divided into treatment group (36 cases) and control group (37 cases). Two groups of children were given the expectorant, antitussive, anti-asthmatic, and anti-infection treatment, the patients in treatment group were given Huaiqihuang Granules. The changes of clinical therapeutic effect and immune index in two groups after treatment for 1 month were compared. Results The time of cough was (5.3±1.8) d, shortness of breath time was (2.7±1.4) d, and lung roar cries sound time was (4.9±1.6) d, pulmonary rales time was (5.2±1.7) d, and length of hospital stay was (6.8±1.7) d in research group, which were significantly lower than those in the control group and the difference was statistically significant (P<0.05). Before treatment, the levels of IgE, IgM, IgA, IgG, INF-γ, and IL-4 in treatment group and control group had no statistical significance. After treatment for 1 month, the detection values of IgE, IgA, INF-γ, and IL-4 in two groups were all better than those before treatment and the difference was statistically significant (P<0.05). The IgE and IL-4 levels in treatment group were significantly lower than the control group, the detection values of IgA, INF-γ was significantly higher than the control group (P<0.05). The markedly effective rate of research group was 86.11%, significantly higher than that of control group with 62.16% (P<0.05); after treatment, the effective rate of study group was 97.22%, higher than that of the control group with 91.89%, but the difference is not statistically significant. Conclusion Huaiqihuang Granule could regulate the function of humoral immunity in children with RSV bronchiolitis, at the same time, it could promote the relief of clinical symptoms of patients, could improve the therapeutic effect.