3 mIU/mL患者數(shù)為8例,明顯高于對(duì)照組的4例,兩組比較差異有統(tǒng)計(jì)學(xué)意義(P<0.05);觀察組血HCG最高滴定值>105 mIU/mL患者數(shù)為6例,明顯低于對(duì)照組的18例,兩組比較差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。兩組患者不同程度出現(xiàn)白細(xì)胞減少、惡心、嘔吐、口腔潰瘍等不良反應(yīng),但組間差異無統(tǒng)計(jì)學(xué)意義。結(jié)論 5-Fu聯(lián)合甲氨蝶呤治療惡性滋養(yǎng)細(xì)胞腫瘤療效確切且安全可靠,值得臨床推廣應(yīng)用。;Objective To investigate the clinical efficacy of 5-fluorouracil (5-Fu) combined with methotrexate in the treatment of malignant trophoblastic tumor. Methods Taking admission number as number, according to the random number table, 80 patients diagnosed as malignant tumor were randomly divided into two groups, 40 cases in each group. Patients in control group were treated with 5-Fu chemotherapy; Patients in observation group were treated with 5-Fu combined with methotrexate. The changes of blood HCG, clinical symptoms, efficacy, and adverse reactions of two groups of patients after treatment were observed. Results After treatment, the clinical effective rate of observation group (97.5%) was significantly higher than that in the control group (85%) (P<0.05). After treatment, the number of patients with the highest HCG value of blood less than 103 mIU/mL in observation group (8 cases) were significantly higher than the control group (4 cases) (P<0.05); The number of patients with the highest HCG value of blood more than 105 mIU/mL in the observation group (6 cases) was significantly lower than that in the control group (18 cases) (P<0.05). There were different degree of adverse reactions in patients with leukopenia, nausea, vomiting, oral ulcer, but no significant difference between the groups. Conclusion 5-Fu combined with methotrexate is effective and safe in the treatment of malignant tumor. It is worthy of clinical application."/>