目的 探討卡前列素氨丁三醇、米索前列醇和縮宮素聯(lián)合應(yīng)用治療產(chǎn)后出血的療效。方法 選擇2013年2月-2015年9月在渭南市婦幼保健院進(jìn)行診治的產(chǎn)后出血患者100例,隨機(jī)分為兩組,其中觀察組55例,給予卡前列素氨丁三醇、米索前列醇和縮宮素聯(lián)合治療;對(duì)照組45例,給予縮宮素治療,觀察兩組的臨床療效、術(shù)中出血量、術(shù)后2 h出血量、術(shù)后24 h出血量、產(chǎn)后出血持續(xù)時(shí)間和住院時(shí)間,記錄兩組不良反應(yīng)的發(fā)生情況。結(jié)果 與對(duì)照組相比,觀察組的術(shù)中出血量、術(shù)后2 h出血量和術(shù)后24 h出血量均明顯減少(P<0.05);觀察組的治療總有效率為92.73%(51/55),明顯高于對(duì)照組80.00%(36/45)(P<0.05);觀察組的產(chǎn)后出血持續(xù)時(shí)間和住院時(shí)間均明顯短于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P<0.05);兩組間不良反應(yīng)發(fā)生率相比,差異無統(tǒng)計(jì)學(xué)意義。結(jié)論 卡前列素氨丁三醇、米索前列醇和縮宮素聯(lián)合應(yīng)用治療產(chǎn)后出血療效顯著,能夠有效減少術(shù)后出血量,縮短止血時(shí)間和住院時(shí)間,安全有效,值得臨床應(yīng)用推廣。

Objective To explore the clinical effective of carboprost tromethamine and misoprostol combined with oxytocin in treatment of postpartum hemorrhage. Methods Totally 100 cases of patients with postpartum hemorrhage were treated in Weinan Matemty and Child Health Care Hospital from January 2013 to September 2015, and they were randomly divided into observation group (55 cases) and control group (45 cases). The patients in observation group were treated with carboprost tromethamine and misoprostol combined with oxytocin, the control group was treated with oxytocin. The clinical effect of the two groups, the amount of intraoperative hemorrhage volume, postoperative 2 h bleeding, postoperative 24 h bleeding volume, duration time of postpartum hemorrhage and hospitalization time, and occurrence of adverse reactions in the two groups were observed. Results Compared with the control group, the amounts of blood loss, 2 h postoperative bleeding volume, and 24 h postoperative bleeding volume were significantly decreased (P<0.05); The total effective rate of observation group was 92.73% (51/55) which was significantly higher than that in control group 80.00% (36/45) (P<0.05); The duration time of postpartum hemorrhage and hospitalization time in the observation group were significantly shorter than tht in control group (P<0.05); The adverse reaction rate between the two groups was not statistically significant. Conclusion The curative effect of carboprost tromethamine, misoprostol combined with oxytocin in treatment of postpartum hemorrhage is remarkable, can effectively reduce the amount of bleeding, shorten the time of bleeding and hospitalization time, safe and effective, which is worthy of clinical application.