目的 觀察分析枸櫞酸咖啡因與氨茶堿治療早產(chǎn)兒呼吸暫停的臨床效果。方法 選取2014年6月-2015年6月經(jīng)診斷為原發(fā)性呼吸暫停患兒80例為研究對象,按隨機(jī)數(shù)字表法分為對照組40例和觀察組40例,對照組給予常規(guī)護(hù)理配合氨茶堿注射液治療;觀察組給予常規(guī)護(hù)理配合枸櫞酸咖啡因治療。觀察患兒的PCO₂、PaO₂檢測值,患兒呼吸暫停的發(fā)作次數(shù)、發(fā)作時(shí)間、癥狀消除時(shí)間,并對治療效果和不良反應(yīng)進(jìn)行觀察分析。結(jié)果 治療后兩組PCO₂、PaO₂檢測值均有所變,與治療前比較差異有統(tǒng)計(jì)學(xué)意義(P<0.05);治療后組間比較,觀察組變化更顯著(P<0.05);觀察組患兒呼吸暫停次數(shù)、發(fā)作持續(xù)時(shí)間、癥狀消失時(shí)間均小于對照組,兩組對比差異有統(tǒng)計(jì)學(xué)意義(P<0.05);觀察組患兒治療總有效率為75%,對照組為50%,差異有統(tǒng)計(jì)學(xué)意義(P<0.05);觀察組不良反應(yīng)為5%,對照組不良反應(yīng)為20%,差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論 枸櫞酸咖啡因在治療患兒呼吸暫停方面效果優(yōu)于氨茶堿,且不良反應(yīng)小,臨床值得推廣。

Objective To observe and analyze the clinical effect of caffeine citrate and aminophylline on premature infant with apnea. Methods Totally 80 cases of children diagnosed with primary apnea from June 2014 to June 2015 were chosen as the research object, then randomly divided into control group with 40 cases and observation group with 40 cases. The patients in control group were given routine nursing combined with aminophylline injection treatment; The patients in observation group were given routine nursing combining with caffeine citrate treatment. The readings of patient's PCO₂ and PaO₂, the frequency of apnea, duration time of apnea symptoms, and relax time were observed, and the therapeutic effect and adverse reactions were analyzed. Results After treatment, the readings of PaCO₂ and PaO₂ in two groups both changed, the difference showed statistical significance compared with that before treatment (P<0.05); Comparison between groups after treatment, the changes in observation group were more obvious (P<0.05); the frequency of apnea, duration time of apnea symptoms and the relax time in observation group were less than those in control group, the difference showed statistical significance (P<0.05); The total effective rate in observation group reached 75% and that in the control group was 50%, the difference was statistically significant (P<0.05); The adverse reaction rate in observation group was 5%, and that in control reached 20%, the difference showed statistical significance (P<0.05). Conclusion The treatment of caffeine citrate on children with apnea shows a better effects with small adverse reactions, and is worthy of clinical spreading.