核因子E2相關(guān)因子2(nuclear factor E2 related factor 2, Nrf2)是諸多細(xì)胞信號(hào)通路中最重要的一種,是一種基礎(chǔ)轉(zhuǎn)錄調(diào)節(jié)因子,主要編碼表達(dá)多種重要的細(xì)胞保護(hù)因子,包括解毒酶、抗氧化蛋白、外排型轉(zhuǎn)運(yùn)體、抗凋亡蛋白、抗炎因子以及其他的應(yīng)激反應(yīng)因子。在肝臟或腎臟因外界條件造成損傷時(shí),Nrf2通過(guò)調(diào)節(jié)細(xì)胞對(duì)毒物的代謝排泄、細(xì)胞凋亡以及在應(yīng)激狀態(tài)下細(xì)胞的抗炎抗氧化進(jìn)程而發(fā)揮作用。對(duì)Nrf2在肝臟、腎臟損傷中的保護(hù)作用及其分子機(jī)制做一綜述,以期為新藥研發(fā)提供理論依據(jù)。

Multifaceted cell defense pathways play the critical role in the maintenance of homeostasis in life. The nuclear factor E2 related factor 2(Nrf2) pathway is one of the most important cytoprotective pathways, with Nrf2 serving as a master transcriptional regulator of the basal and inducible expression of a multitude of genes encoding detoxification enzymes, anti-oxidant proteins, xenobiotic transporters, anti-apoptotic proteins, anti-inflammatory cytokine and many other stress-response mediators. Liver and kidney injury, induced by some stimuli, could be repaired by the regulation of endogenous and exogenous stresses, apoptosis, inflammatory and oxidative stress. This review provides an update on the mechanism and highlights the beneficial role of Nrf2 which might be a new target of drug development in hepatoprotection and renal protection.

國(guó)家自然科學(xué)基金資助項(xiàng)目(81273580,81473280)