目的 探討乳酸左氧氟沙星注射液所致不良反應（ADR）的特點，并對安全性進行評價，以促進臨床合理用藥。方法 對2010年3月-2015年8月間于榆林星元醫(yī)院進行乳酸左氧氟沙星注射后發(fā)生ADR的76例患者進行回顧性分析，對患者一般情況、用藥情況以及不良反應表現(xiàn)進行考察。結果 76例ADR病例當中，男性占51.32%，女性占48.68%?；颊吣挲g以61～80歲所占構成比最大；原患疾病以呼吸系統(tǒng)感染所占構成比最大，占全部病例的47.37%；用藥劑量以每次300 mg的患者所占構成比最大，為51.3%；聯(lián)合用藥占21.05%，以頭孢菌素類聯(lián)用最為多見；給藥后24 h內發(fā)生ADR病例所占構成比最大；共出現(xiàn)51例單一器官受累及33例多重器官受累，以消化系統(tǒng)和皮膚受累所占構成比最高；好轉33例，痊愈43例。結論 乳酸左氧氟沙星在臨床各種疾病的治療中均可能出現(xiàn)不良反應，在使用該藥物進行治療時，必須進行合理應用與不良反應監(jiān)測，以保障患者用藥安全。

Objective To explore adverse drug reaction (ADR) of levofloxacin lactate injection, and make safety assessment for their rational use in clinic. Methods Totally 76 cases of adverse reaction of levofloxacin lactate injection in Xing Yuan (4th) Hospital of Yulin from March 2010 to August 2015 were retrospectively analyzed. General data, medications, and adverse reaction appearance was observed. Results Among 76 cases of ADR of levofloxacin lactate injection, there were 51.32% male and 48.68% female. Patients of 61-80 years old had the largest number. Patients underlying respiratory infections had largest proportion of 47.37%. Levofloxacin lactate injection was given with the dose of 300 mg/time with the percentage of 51.3%. Results The drug combination had a percentage of 21.05%, and cephalosporin had the largest proportion. ADR always happened in 24 h after medication, there were 51 cases single and 33 multi organ or system involved, and the largest number among them was digestive system and skin. The results of ADR were 33 cases better and 43 cases recovery. Conclusion ADR can happen in using Levofloxacin Lactate Injection to treat diseases in many organs and systems. It means that we have to reasonably apply and monitor ADR in time to ensure patients administration security.