O/W was calculated with concentration ratio of ambroxol hydrochloride in n-octanol and water phase after partition equilibrium. Results The equilibrium solubility of ambroxol hydrochloride is high in various solvents, especially at distilled water, pH 2.0 and pH 5.8, the equilibrium solubility are 26.04, 27.71, 28.24 mg/mL; And the maximum of apparent partition coefficient is 60.80 at pH 7.4. Conclusion The equilibrium solubility and apparent partition coefficient of ambroxol hydrochloride are correlated to pH of the medium. And it can be inferred that ambroxol hydrochloride can be absorbed by the gastrointestinal and has better using value."/>

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首頁 > 過刊瀏覽>2016年第39卷第4期 >2016,39(4):615-618. DOI:10.7501/j.issn.1674-6376.2016.04.019
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鹽酸氨溴索平衡溶解度和表觀油水分配系數(shù)的測定

Determination of equilibrium solubility and apparent oil/water partition coefficient of ambroxol hydrochloride

發(fā)布日期:2016-07-22
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