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[摘要]
目的 觀察依達(dá)拉奉聯(lián)合丁苯酞治療急性腦梗死的臨床療效。方法 選取200例在寶雞市人民醫(yī)院就診的急性腦梗死患者,隨機分為觀察組100例,給予依達(dá)拉奉注射液聯(lián)合丁苯酞治療,對照組100例,僅給予丁苯酞治療。對兩組患者的臨床療效、NDS評分、MoCA評分、ADL評分及血清C-反應(yīng)蛋白(hs-CRP)水平及不良反應(yīng)進(jìn)行比較。結(jié)果 觀察組總有效率(92%)顯著高于對照組(79%),差異具有統(tǒng)計學(xué)意義(P<0.05)。治療后兩組患者神經(jīng)功能缺損均有所下降,認(rèn)知功能均有所改善,但觀察組神經(jīng)功能缺損下降顯著低于對照組,認(rèn)知功能改善優(yōu)于對照組,觀察組ADL評分顯著高于對照組,hs-CRP水平顯著低于對照組,差異具有統(tǒng)計學(xué)意義(P<0.05)。所有患者治療過程中無明顯不良反應(yīng)。結(jié)論 依達(dá)拉奉注射液聯(lián)合丁苯酞對急性腦梗死療效顯著,安全性好,值得臨床推廣。
[Key word]
[Abstract]
Objective To observe the clinical effect of edaravone combined with butylphthalide in the treatment of acute cerebral infarction. Methods Totally 200 cases of acute cerebral infarction in Cadre Ward of Baoji City People Hospital were randomly divided into observation group and control group, each group had 100 cases. The patients in observation group were given edaravone combined with butylphthalide, and the patients in control group were given butylphthalide treatment. The clinical efficacy, NDS score, MoCA score, and adverse reaction of the two groups were compared. Results The total effective rate of observation group (92%) was significantly higher than that of control group (79%), and the difference was statistically significant (P<0.05). After treatment, two groups of patients with neurological deficits were decreased, cognitive function was improved, but the observation group was significantly lower than the control group, the improvement of cognitive function was better than the control group, ADL score of observation group was significantly higher than that of the control group, hs-CRP levels were significantly lower than the control group, the difference was statistically significant (P<0.05). All patients had no obvious adverse reactions during the treatment. Conclusion Edaravone combined with butylphthalide significantly on acute cerebral infarction curative effect, good safety, and is worthy of clinical promotion.
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