目的 觀察硝苯地平聯(lián)合硫酸鎂治療妊娠高血壓疾病的臨床療效。方法 選取禮泉縣民源醫(yī)院收治的妊娠高血壓疾病患者中符合標準的100例患者做為研究對象，分為觀察組和對照組各50例。對照組給予硫酸鎂靜脈滴注治療，觀察組在給予硫酸鎂靜脈滴注治療的基礎上聯(lián)合口服硝苯地平進行治療，觀察兩組治療后的臨床效果。檢測患者收縮壓和舒張壓，比較治療前后的變化情況；測量兩組患者治療前后尿蛋白水平、血黏度、紅細胞壓積（PCV）、胎兒臍動脈收縮壓與舒張壓的比值（S/D）、C反應蛋白（CPR）及CD⁴⁺/CD⁸⁺變化情況。對兩組患者治療后進行追蹤預后，比較產婦及新生兒結局：終止妊娠、自然分娩、早產、新生兒窒息的發(fā)生率。結果 觀察組總有效率為94%，明顯高于對照組總有效率74%（P<0.05）；治療后兩組患者血壓較治療前有明顯降低（P<0.05）；觀察組比對照組降低更明顯，組間比較差異具有統(tǒng)計學意義（P<0.05）。治療后兩組尿蛋白水平均顯著下降（P<0.05）；觀察組尿蛋白水平明顯低于對照組（P<0.05）。治療后兩組患者血黏度、PCV、S/D、CPR及CD⁴⁺/CD⁸⁺都明顯改善，與治療前比較差異顯著（P<0.05），且觀察組各指標改善情況明顯優(yōu)于對照組，兩組比較差異具有統(tǒng)計學意義（P<0.05）。治療后，觀察組患者自然分娩率明顯高于對照組患者，觀察組產婦終止妊娠、早產及新生兒窒息的發(fā)生率明顯低于對照組，兩組比較差異有統(tǒng)計學意義（P<0.05）。結論 硝苯地平聯(lián)合硫酸美治療妊娠高血壓療效明顯，具有臨床推廣價值。

Objective To observe the curative effect of Nifedipine combined with Magnesium Sulfate on the treatment of pregnancy-induced hypertension. Methods Totally 100 cases diagnosed with pregnancy-induced hypertension were selected and divided into observation group and control group randomly, 50 cases in each group. The patients in control group were treated with iv infusion of Magnesium Sulfate. The patients in observation group were given Magnesium Sulfate combined with oral nifedipine. Then the clinical effect of the two groups after treatment were observed. To detect the patient's systolic blood pressure and diastolic blood pressure, and compare the changes before and after treatment. The levels of urinary protein, blood viscosity, red blood cell (PCV), fetal umbilical artery systolic blood pressure and diastolic blood pressure (S/D), C reactive protein (CPR) and CD⁴⁺/CD⁸⁺ were measured before and after treatment in two groups. After treatment, two groups of patients were followed to prognosis, compared with the maternal and neonatal outcomes, including termination of pregnancy, spontaneous labor, premature birth, and neonatal asphyxia incidence. Results The total effective rate in observation group was 94%, which was significantly higher than that of 74% in control group (P<0.05). Blood pressure in the two groups after treatment was significantly lower than before treatment (P<0.05), and that of the observation group was significantly lower than the control group (P<0.05). After treatment, the levels of urinary protein in the two groups were significantly decreased (P<0.05); the level of urinary protein in the observation group was significantly lower than that in the control group (P<0.05). After treatment, blood viscosity, PCV, S/D, CPR and CD⁴⁺/CD⁸⁺ of two groups were significantly improved (P<0.05), and the observation group, each index improved significantly better than the control group (P<0.05). After treatment, natural childbirth rate of observation group was significantly higher than that of the control group,maternal termination of pregnancy, premature birth and neonatal asphyxia incidence of observation group was significantly lower than that of the control group, the difference between the two groups has statistical significance (P<0.05). Conclusion The treatment of Nifedipine combined with Magnesium Sulfate on the patients with pregnancy-induced hypertension shows obvious therapeutic effect, which is worthy of clinical popularization.