目的 探析硝苯地平控釋片聯(lián)合倍他樂克治療原發(fā)性高血壓的臨床療效。方法 將100例渭南市婦幼保健院住院部收治的原發(fā)性高血壓患者按隨機頻數(shù)表均分為觀察組和對照組各50例，觀察組以硝苯地平控釋片和倍他樂克治療，對照組只以硝苯地平控釋片處理，治療前后均對兩組患者的24 h動態(tài)血壓、心率及不良反應詳細記錄，連續(xù)治療8周后，對比各項指標的變化分析治療效果及安全性。結(jié)果 治療后兩組患者24 h收縮壓、舒張壓和心率均明顯下降，與治療前比較差異顯著（P<0.05）。治療后，觀察組24 h收縮壓、舒張壓和心率均明顯低于對照組，差異顯著（P<0.05）。觀察組收縮壓和舒張壓的谷峰比均明顯高于對照組，差異顯著（P<0.05），表明觀察組血壓控制更平穩(wěn)。連續(xù)治療8周后，觀察組總有效率為96.0%，對照組總有效率為78.0%，兩組比較差異有統(tǒng)計學意義（P<0.05）。觀察組不良反應率8%明顯低于對照組的22%，兩組比較差異有統(tǒng)計學意義（P<0.05）。結(jié)論 硝苯地平控釋片聯(lián)合倍他樂克治療原發(fā)性高血壓不僅有效，而且大大降低了藥物的副作用，是臨床的合理選擇。

Objective To analyze the clinical effect of Nifedipine Controlled Release Tablets with metoprolol on treatment of essential hypertension. Methods Totally 100 cases of patients with essential hypertension were randomly divided into observation group and control group, 50 cases in each group. The patients in observation group were treated with Nifedipine Controlled Release Tablets and metoprolol, and the patients in control group were only treated with Nifedipine Controlled Release Tablets. Then the 24-h ambulatory blood pressure, heart rate, and adverse reaction in both groups before and after treatment were observed. After 8 weeks of continuous treatment, the therapeutic effect and safety of the changes of indexes were analyzed. Results After treatment, the 24 h systolic pressure, diastolic pressure, and heart rate of two groups were significantly decreased than before treatment (P<0.05). The 24 h systolic pressure, diastolic pressure, and heart rate of observartion group were significantly lower than those in the control group (P<0.05). The systolic pressure, diastolic pressure trough-to-peak ratios of observation group were significantly higher than those of the control group (P<0.05). The blood pressure of observation group was controlled more smoothly. After treatment for 8 weeks, the total efficacy of observation group was 96.0%, while the control group was 78.0%, which had significant difference (P<0.05). The adverse reaction rate of observation group was 8%, while that in the control group was 22%, which had significant difference (P<0.05). Conclusion Nifedipine Controlled Release Tablets combined with metoprolol in the treatment of primary hypertension is not only effective, but also greatly reduces the side effects of drugs, and it is a reasonable choice.