卵巢早衰是由多種致病因素引起的卵巢功能衰竭性疾病，發(fā)病率呈逐年上升趨勢，嚴(yán)重影響了女性的正常生活。坤泰膠囊由《傷寒論》中的古方化裁而來，能夠有效調(diào)節(jié)女性內(nèi)分泌水平、改善卵巢功能、治療卵巢功能衰退，可單用或與性激素聯(lián)合用于卵巢早衰的治療。大鼠毒理學(xué)研究證實(shí)坤泰膠囊無明顯生殖毒性，大量臨床研究也表明其安全性較好。對(duì)坤泰膠囊改善卵巢早衰的動(dòng)物毒理和臨床研究進(jìn)展進(jìn)行綜述，為其在臨床上推廣應(yīng)用提供依據(jù)。

Premature ovarian failure (POF) is caused by a variety of pathogenic factors, and the morbidity of POF is increasing year by year, seriously affecting the normal life of women. Kuntai Capsule is originated from ancient traditional Chinese medicine prescriptions, and has the effect of adjusting the hormone secretion and improving the ovarian function. It could be used alone or in combination with sex hormone in the treatment of premature ovarian failure. The toxicology studies in rats demonstrated no obvious reproductive toxicity; and a large number of clinical studies have confirmed its safety. This present review summarized the clinical application of Kuntai Capsule in the treatment of patients with POF, providing a basis for the further application of Kuntai Capsule.

河北省重大醫(yī)學(xué)科研項(xiàng)目（No.zyzd2013018）；河北省政府資助臨床醫(yī)學(xué)優(yōu)秀人才培養(yǎng)項(xiàng)目（No.2014571024）；河北省中醫(yī)藥管理局中醫(yī)藥科研計(jì)劃課題資助項(xiàng)目（No.2016068）；高慧全國名老中醫(yī)藥專家傳承工作室建設(shè)項(xiàng)目（No.2015048157）