[關(guān)鍵詞]
[摘要]
目的 研究圣曲紅曲膠囊治療頸動脈粥樣硬化的療效。方法 選擇經(jīng)彩色多普勒超聲檢出的120例頸動脈粥樣硬化患者,隨機分為2組,每組60例。治療組口服圣曲紅曲膠囊4粒/次,3次/d,連續(xù)服用24周;對照組口服辛伐他汀20 mg/d,連續(xù)服用24周,兩組分別在治療前、治療中(第12周)檢測血脂數(shù)據(jù)及檢查頸動脈內(nèi)膜中層厚度(IMT),在治療后(第24周)檢測氧化低密度脂蛋白(oxLDL)及IMT。結(jié)果 治療組與對照組12周數(shù)據(jù)與治療前比較,三酰甘油(TG)分別降低55.60%和47.62%,總膽固醇(TC)分別降低27.13%和23.95%,低密度脂蛋白膽固醇(LDL-C)分別降低28.18%和28.70%,以上三項數(shù)據(jù)兩組間比較均無顯著性差異;治療組第12周數(shù)據(jù)與治療前比較高密度脂蛋白膽固醇(HDL-C)升高46.79%,對照組HDL-C無顯著變化,兩組比較差異顯著(P<0.05);與治療前比較,治療后兩組oxLDL和IMT均顯著降低,差異有統(tǒng)計學(xué)意義(P<0.05),兩組間差異無統(tǒng)計學(xué)意義。結(jié)論 圣曲紅曲膠囊不僅具有調(diào)脂作用,還能減輕頸動脈粥樣硬化病變,消退頸動脈粥樣硬化斑塊和減輕炎癥反應(yīng),具有穩(wěn)定并逆轉(zhuǎn)斑塊的作用,逆轉(zhuǎn)斑塊的作用與辛伐他汀相當。
[Key word]
[Abstract]
Objective To study the effect of Shengqu Hongqu Capsules in the treatment of patients with carotid atherosclerosis, and to determine the time and course of treatment of Shengqu Hongqu Capsules. Methods Totally 120 patients with carotid atherosclerosis detected by color Doppler ultrasound were randomly divided into two groups, 60 cases in each group. The first treatment group (oral Shengqu Hongqu Capsules 4 capsules each time, 3 times a day) were administered for 24 weeks; Second control groups (Simvastatin 20 mg daily) were administered for 24 weeks, the two groups respectively before treatment, treatment (12th week) and blood lipid data to detect the carotid artery intima-media thickness (detection IMT), in the two groups after treatment (24th week) oxLDL examination of carotid artery intima-media thickness (IMT) detection. Results the treatment group compared with the control group for 12 weeks and data before treatment, TG decreased by 55.60% and 47.62%, TC were decreased by 27.13% and 23.95%, LDL-C were decreased by 28.18% and 28.70%, more than three data showed no significant difference (P > 0.05); Compared with before treatment, in 12th week treatment group data, HDL-C increased by 46.79%, the control group was HDL-C change; Compared with before treatment, after treatment two groups of carotid artery intima-media thickness (IMT) were significantly decreased, the difference was statistically significant between the two groups, the carotid intima-media thickness (IMT) was not statistically significant decrease. Conclusion Shengqu Hongqu Capsules not only has lipid-lowering effect, but also can significantly reduce the carotid atherosclerotic lesions and reduce inflammation, with stable and reverse the plaque, and the effect was as good as simvastatin.
[中圖分類號]
[基金項目]
浙江省醫(yī)院管理軟科學(xué)研究(2011-ZHA-KEB330)