目的 探討泮托拉唑與奧曲肽治療上消化道出血的療效。方法 選取了220例上消化道出血患者，按隨機(jī)數(shù)字表法分為兩組，觀察組（115例）給予奧曲肽聯(lián)合泮托拉唑治療，對照組（105例）給予泮托拉唑治療，觀察兩組療效、圍手術(shù)期指標(biāo)、SF-36評分及隨訪1個月期間不良反應(yīng)情況，評價泮托拉唑與奧曲肽治療上消化道出血的療效。結(jié)果 治療后觀察組有效率明顯高于對照組（P<0.05），觀察組出血時間短于對照組，輸血量少于對照組；血紅蛋白水平，胃液PH值顯著高于對照組（P<0.05），治療前，兩組SF-36量表各項(xiàng)評分相比，無統(tǒng)計學(xué)差異。治療后1個月，觀察組在生理功能、生理職能、軀體疼痛上評分均明顯高于對照組（P<0.05），其余各項(xiàng)評分相比無統(tǒng)計學(xué)差異，隨訪1個月期間，兩組不良反應(yīng)無統(tǒng)計學(xué)差異。結(jié)論 奧曲肽聯(lián)合泮托拉唑?qū)ι舷莱鲅哂休^好療效，能夠迅速止血，減少血液流失和輸血量，改善患者生活質(zhì)量，用藥具有安全性，值得臨床推廣使用。

Objective Discuss the efficacy of pantoprazole and octreotide in treatment of gastrointestinal hemorrhage.Methods Selecting 220 cases patients with gastrointestinal hemorrhage. They were divided into two groups randomly. The observation group (115 cases) was given pantoprazole combined with octreotide. The observation group (105 cases) was given pantoprazole. The efficacy of pantoprazole and octreotide in treatment of gastrointestinal hemorrhage was evaluated by efficacy, perioperative index, SF-36 scores and adverse reaction during 1 month follow-up.Results The effective rate of observation group was significantly higher than that of the control group (P<0.05). The bleeding time of observation group was shorter than that of control group (P<0.05). The blood transfusion of observation group was less than that of control group (P<0.05). The hemoglobin level and PH value observation group was higher than that of control group (P<0.05). Before treatment, there were no statistical significance on SF-36 scores. After 1 months treatment, physiological function, physical function and pain scores of observation group was higher than that of control group (P<0.05). During 1 months follow-up, there were no statistical significance on adverse reaction between two groups.Conclusion The pantoprazole combined with octreotide had a good therapeutic effect on gastrointestinal hemorrhage. It could stop bleeding quickly, reduce blood loss and blood transfusion. It could improve the quality of life and use safely with worthy of clinical use.