目的 觀察消旋卡多曲顆粒聯(lián)合炎琥寧注射液對輪狀病毒腸炎（RVE）患兒心肌的保護(hù)作用，探討其相關(guān)的作用機(jī)制和臨床療效。方法 選取鄂東醫(yī)療集團(tuán)黃石市中醫(yī)醫(yī)院2013年12月-2016年6月治療的RVE患兒116例，隨機(jī)分為消旋卡多曲顆粒對照組和消旋卡多曲顆粒聯(lián)合炎琥寧注射液觀察組，每組58例。使用ELISA法測定肌酸激酶（CK）、肌酸激酶同工酶（CK-MB）、乳酸脫氫酶（LDH）、白介素-17（IL-17）、白介素-6（IL-6）和腫瘤壞死因子-α（TNF-α），比較兩組的臨床有效率和不良反應(yīng)。結(jié)果 治療前兩組CK、CK-MB、LDH、IL17、IL-6和TNF-α表達(dá)無顯著性差異，治療后兩組上述指標(biāo)均顯著降低（P<0.05、0.01），但觀察組對上述指標(biāo)的減低作用顯著高于對照組（P<0.05）。觀察組臨床治療有效率為94.8%，顯著高于對照組的81.0%（P<0.05）。觀察組臨床治療不良反應(yīng)率為8.6%，對照組的不良反應(yīng)率為6.9%，兩組比較無顯著性差異。結(jié)論 消旋卡多曲顆粒聯(lián)合炎琥寧注射液治療小兒輪狀病毒腸炎可以抑制炎癥反應(yīng)，保護(hù)患兒心肌損傷，臨床療效顯著，且使用安全。

Objective To observe the protective effect of Racecadotril combined with Succinate Injection on myocardial injury in children with rotavirus enteritis and explore its clinical significance.Methods Totally 116 cases of children with rotavirus enteritis from Huangshi Traditional Chinese Medicine of Edong Healthcare Group were selected in this study. Patients were randomly divided into Racecadotril control group (n=58) and Racecadotril combined with Succinate Injection observation group (n=58). The levels of CK, CK-MB, LDH, IL-17, IL-6, and TNF-α were detected by ELISA analysis. The rates of clinic effects and adverse reaction were compared.Results There was no significant difference of CK, CK-MB, LDH, IL-17, IL-6, and TNF-α between two groups before treatment. After treatment, they were all decreased in two groups (P<0.05, 0.01). However, they were all lower in observation group than those in control group after treatment (P<0.05). The rate of clinic effects was 94.8% in observation group, which was higher than 81.0% in control group (P<0.05). The rate of adverse reaction was 8.6% in observation group and 6.9% in control group. There was no significant difference between two groups.Conclusion Racecadotril combined with Succinate Injection inhibits the inflammatory response to protect myocardial injury in RVE children, with significantly clinical efficacy and safety.