目的 比較氨磺必利與氯氮平治療陰性癥狀為主的精神分裂癥的療效及安全性。方法 以2013年5與—2016年5月河北省第六人民醫(yī)院收治的陰性癥狀為主的精神分裂癥患者166例為研究對象，根據(jù)入組順序隨機分為觀察組和對照組，每組83例，對照組采用氯氮平治療，觀察組采用氨磺必利治療，兩組均連續(xù)治療12周。比較兩組在治療2、4、8、12周時的臨床療效、陰性癥狀評定量表（SANS）評分和心電圖異常發(fā)生率。結(jié)果 治療4、8、12周時，觀察組的治療總有效率（37.35%、60.24%、63.86%）與對照組（39.76%、49.40%、66.27%）比較，差異均無統(tǒng)計學(xué)意義；治療4、8、12周時，兩組的SANS量表中的5項指標評分均較治療前顯著降低（P＜0.05），且隨著治療時間的延長，評分均呈下降趨勢；治療第4、8、12周時，觀察組的情感平淡或遲鈍和注意障礙評分均顯著低于對照組（P＜0.05），但兩組間思維貧乏、意志缺乏和興趣/社交缺乏評分比較，差異均無統(tǒng)計學(xué)意義。治療12周時，觀察組的心電圖異常率顯著低于對照組（P＜0.05）。結(jié)論 與氯氮平相比，氨磺必利治療以陰性癥狀為主的精神分裂癥的臨床療效相當，但改善情感平淡或遲鈍和注意障礙效果更顯著，且心電圖異常發(fā)生率低。

Objective To investigate the efficacy and safety of amisulpride and clozapine in schizophrenia patients with predominantly negative symptoms. Methods Totally 166 cases of schizophrenia patients with predominantly negative symptoms from May 2013 to May 2016 in The Sixth People's Hospital of Hebei were divided into observation group and control group, 83 cases in each group. Patients in the observation group were treated with amisulpride, and control group were treated with clozapine. The clinical effect, SANS scores, and occurring rate of abnormal electrocardiogram were compared. Results The clinical effect, emotional insipid (blunting), and attention dysfunction scores from SANS of observation group were significantly better than those of control group on week 4, 8, and 12, respectively (P< 0.05); The occurring rate of abnormal electrocardiogram in observation group was significantly lower than that of control group on week 12 (P< 0.05). Conclusion Compared with clozapine, amisulprid has better efficacy and safety in schizophrenia patients with predominantly negative symptoms, and can effectively improve of symptom of insipid (blunting) and attention dysfunction.