目的 探討水飛薊賓對高脂誘導的非酒精性脂肪肝（NAFL）模型大鼠的調(diào)脂保肝作用。方法 采用ig高脂乳劑配合高脂飼料制備大鼠NAFL模型，持續(xù)4周，對照組給予生理鹽水和普通飼料。模型大鼠隨機分為模型組、辛伐他?。栃运帲?.8 mg/kg）組和水飛薊賓低、中、高劑量（18.9、37.8、75.6 mg/kg）組，第5周在繼續(xù)造模的基礎(chǔ)上ig給藥，每天1次，持續(xù)8周。末次給藥后，稱取肝臟質(zhì)量并計算肝系數(shù)；HE染色觀察肝組織病理形態(tài)；腹主動脈取血，分離血清，試劑盒法檢測三酰甘油（TG）、總膽固醇（TC）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、天冬氨酸轉(zhuǎn)氨酶（AST）、丙氨酸轉(zhuǎn)氨酶（ALT）水平。結(jié)果 連續(xù)治療8周后，與對照組比較，水飛薊賓高、中劑量均可明顯改善肝組織脂肪變性程度；各劑量組肝系數(shù)均顯著下降（P<0.05、0.01）；各劑量組均顯著降低血清TC、TG、AST、ALT水平（P<0.05、0.01）；高、中劑量組顯著降低LDL、升高HDL水平（P<0.01）。結(jié)論 水飛薊賓對NAFL大鼠發(fā)揮治療作用，其作用可能與降脂、保肝有關(guān)。

Objective To investigate the lipid hepatoprotective effect of silibinin on high fat diet-induced nonalcoholic fatty liver (NAFL) rat model and provide a theoretical basis for the treatment of silibinin on NAFL. Methods The NAFL rat model was established by administration of high fat emulsion and high fat diet. Rats in control group was treated with saline and normal diet.The model rats were randomly divided into model group, simvastatin (positive drug, 1.8 mg/kg) group,Silibinin groups with low, middle and high doses (18.9, 37.8 and 75.6 mg/kg). From the fifth week, NAFLrats were treated with different drugsonce a day for eight weeks. All rats were anaesthetized afterfinal administration, Livertissues were weighed for the calculation of hepatic coefficientThe hepatic morphology was observed through HE staining. Serum was obtained from abdominal aortic blood fordetection of triglyceride separation (TG), total cholesterol (TC), high density lipoprotein (HDL), low-density lipoprotein (LDL), aspartate aminotransferase (AST),and alanine aminotransferase (ALT) levels.Results After eight-week treatment, compared with model group, middle and high doses of silibinincould significantly improve the hepatic steatosis. The levels of hepatic coefficient, serum TC, TG, AST and ALT in rats treated with individual dose of Silibinin were significantly decreased (P< 0.05, 0.01). Particularly, high dose of silibinin significantly reduced LDL level whereas elevated HDL level in serum (P< 0.01).Conclusion Silibinin has a therapeutic effect on nonalcoholic fatty liver rats, and possible mechanism is related to lipid-lowering and hepatic protection.