目的 分析單唾液酸四己糖神經(jīng)節(jié)苷脂聯(lián)合依達(dá)拉奉治療急性腦梗死的療效及對(duì)血清相關(guān)指標(biāo)的影響。方法 以2010年10月-2016年5月榆林市第一醫(yī)院急診救治的126例急性腦梗死患者為研究對(duì)象，根據(jù)就診順序分為觀察組和對(duì)照組，每組63例。對(duì)照組患者在常規(guī)治療基礎(chǔ)上給予依達(dá)拉奉注射液，觀察組在對(duì)照組的基礎(chǔ)上加用單唾液酸四己糖神經(jīng)節(jié)苷脂鈉注射液，兩組均連續(xù)治療2周。比較兩組的臨床療效，美國(guó)國(guó)立衛(wèi)生研究院卒中量表（NIHSS）評(píng)分、Barthel指數(shù)評(píng)分，血清神經(jīng)元特異性烯醇化酶（NSE）、S100β蛋白、氧化應(yīng)激相關(guān)指標(biāo)[超氧化物歧化酶（SOD）、晚期氧化蛋白產(chǎn)物（AOPP）和丙二醛（MDA）]水平在治療前后的變化情況。結(jié)果 觀察組的總有效率（90.48%）顯著高于對(duì)照組（76.19%），兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療2周后，兩組的NIHSS和Barthel指數(shù)評(píng)分均較治療前顯著降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且觀察組NIHSS和Barthel指數(shù)評(píng)分顯著低于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。兩組的NSE、S100β蛋白、AOPP、MDA水平較治療前顯著降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且觀察組的以上指標(biāo)顯著低于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；SOD水平較治療前顯著升高，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且觀察組的顯著高于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 單唾液酸四己糖神經(jīng)節(jié)苷脂可協(xié)同提高依達(dá)拉奉治療急性腦梗死的臨床療效，促進(jìn)患者神經(jīng)功能及生活能力恢復(fù)，且發(fā)揮協(xié)同作用的機(jī)制可能與協(xié)同改變血清NSE、S100β蛋白、SOD、AOPP、MDA水平有關(guān)。

Objective To investigate the influence of Trisialoganglioside-GT1b combined with Edaravone Injection on clinical effect and serumrelatedindicators in patients with acute cerebral infarction.Methods A total of126 cases of patients with acute cerebral infarction in our hospital from October 2010 to May 2016 were selected and divided into observation group and control group,63 cases in each group.Patients in the control group were treated with regular treatment and Edaravone Injection, and patients in the observation group were treated with regular treatment, Edaravone Injection and Trisialoganglioside-GT1b.The clinical effect, NIHSS scores, Barthel index scores, serum level of neuron specific enolase (NSE), S100β protein, superoxyde dismutase(SOD), advanced oxidation protein products(AOPP) and malondiadehyde(MDA) were compared.Results The total effective rate of the observation group (90.48%) was significantly higher than that of the control group (76.19%), the difference between the two groups was statistically significant (P< 0.05).After two weeks of treatment, two groups of NIHSS and Barthel index scores were significantly lower than before treatment, the difference was statistically significant (P< 0.05); and the NIHSS and Barthel index scores of observation group were significantly lower than that of control group, the difference was statistically significant (P< 0.05).NIHSS scores, Barthel index scores of the observation group were significantly better than that of the control group(P<0.05);The serum level of NSE, S100, AOPP, MDA of two groups after treatment were significantly lower than that before treatment, the difference was statistically significant (P< 0.05); and the above indexes of the observation group was significantly lower than the control group, the difference was statistically significant (P< 0.05); SOD levels of two groups were significantly increased than before treatment, the difference was statistically significant (P< 0.05); and the SOD levels of observation group was significantly higher than that of control group, the difference was statistically significant (P< 0.05).Conclusion Trisialoganglioside-GT1b can synergy improve the clinical effect of Edaravone Injection in patients with acute cerebral infarction, and be good to recovery the neurologicfunctionandabilityofdaily living,and these may be related to the change of the serum level of NSE, S100βprotein, SOD, AOPP and MDA.