2α(PGF2α)、前列腺素E2(PGE2)水平,腦組織中多巴胺(DA)水平;金氏概率相加法計(jì)算Q值,根據(jù)Q值是否大于1判斷元胡止痛滴丸的效果是否優(yōu)于組分單用。結(jié)果 與模型組比較,元胡止痛滴丸、延胡索浸膏和白芷浸膏能夠顯著減少扭體次數(shù)、延長扭體反應(yīng)的潛伏期(P<0.05、0.01、0.001),Q值均大于1;與月月舒比較,元胡止痛滴丸作用顯著增強(qiáng)(P<0.05、0.01)。與模型組比較,元胡止痛滴丸和延胡索浸膏可顯著升高β-EP、PGE2水平(P<0.05、0.01),顯著降低5-HT、NA、DA、PGF2α水平及PGF2α/PGE2比值(P<0.05、0.01、0.001);白芷浸膏可顯著降低5-HT、DA水平(P<0.05、0.01);β-EP、NA、DA和PGE2的Q值均大于1;與月月舒比較,元胡止痛滴丸可顯著升高β-EP、PGE2水平,顯著降低5-HT、PGF2α水平及PGF2α/PGE2比值(P<0.05、0.01)。結(jié)論 元胡止痛滴丸對(duì)痛經(jīng)模型具有顯著的鎮(zhèn)痛作用,作用強(qiáng)度優(yōu)于組分單用,配伍具有合理性,與月月舒比較具有起效早、作用強(qiáng)的特點(diǎn)。;Objective To observe compatibility rationality and comparative advantage of analgesic effect of Yuanhu Zhitong Dropping Pills (YZDP) compared with its ingredient and Yueyueshu through dysmenorrhea model induced by oxytocin.Methods Using dysmenorrhea model induced by ip injection of oxytocin to observe the effect of YZDP, Corydalis extract and Angelica dahurica extract on the latency and times of writhing response, and ELISA method was used to test the level of factors associated with pain in plasma, including 5-serotonin (5-HT), norepinephrine (NA), β-endorphin (β-EP), prostaglandin F2α (PGF2α) and prostaglandin E2 (PGE2), and level of dopamine (DA) in brain tissue. Q value was calculated by prime probability addition method, and according to whether the Q value was greater than one to determine whether the effects of YZDP was better than that of single component.Results Compared with model group, YZDP, Corydalis extract and Angelica dahurica extract could significantly prolong the latency of writhing response, decrease writhing times (P<0.05, 0.01 and 0.001), and the Q values were greater than one. Compared with Yueyueshu, effect of Yuanhuzhitong dropping pills was significantly increased (P<0.05 and 0.01). YZDP and Corydalis extract could increase the level of β-EP as well as PGE2, and decrease the level of 5-HT, NA, DA, PGF2α and the ratio of PGF2α to PGE2 obviously in dysmenorrhea model rats (P<0.05, 0.01 and 0.001). A. dahurica extract can significantly reduce 5-HT and DA level (P<0.05, 0.01). Q values of β-EP, NA, DA and PGE2 were greater than one. Compared with Yueyueshu, YZDP increased the levels of β-EP and PGE2, and decreased the levels of 5-HT, PGF2α and PGF2α/PGE2 significantly (P<0.05 and 0.01).Conclusion YZDP has significant analgesic effect on dysmenorrhea model and has compatibility rationality because of better analgesic effect than ingredient use only. Compared with Yueyueshu, YZDP has the characteristic of working early and better analgesic effect."/>