目的 探討鼠神經(jīng)生長因子（mNGF）治療急性腦梗死的療效及對腦源性神經(jīng)營養(yǎng)因子（BDNF）、胰島素樣生長因子-1（IGF-1）和白細胞介素-33（IL-33）水平的影響。方法 選取2015年10月—2017年2月廊坊市第四人民醫(yī)院收治的急性腦梗死患者106例為研究對象。按照數(shù)字列表法，將患者隨機分為對照組和治療組，每組53例。對照組采取常規(guī)急性腦梗死治療方案，治療組在對照組治療基礎上加用mNGF 18 μg，肌肉注射，1支/次，1次/d，共治療14 d。治療前及治療14 d后應用美國國立衛(wèi)生研究院腦卒中量表（NIHSS）對兩組患者進行神經(jīng)功能缺損程度評分，采用酶聯(lián)免疫吸附法測定血清BDNF、IGF-1和IL-33水平。結果 與治療前比較，兩組患者治療14 d后NIHSS評分均明顯下降，差異有統(tǒng)計學意義（P<0.05）；治療組NIHSS評分下降值明顯大于對照組，差異有統(tǒng)計學意義（P<0.05）。治療組治療后總有效率（93.4%）明顯優(yōu)于對照組（46.6%），差異有統(tǒng)計學意義（P<0.05）。與治療前比較，兩組治療14 d后血清BDNF、IGF-1水平升高，IL-33水平下降，同組治療前后比較差異有統(tǒng)計學意義（P<0.05），但治療組變化程度明顯大于對照組，差異有統(tǒng)計學意義（P<0.05）。結論 mNGF可顯著減輕腦梗死患者神經(jīng)功能缺損程度，并可有效上調BDNF、IGF-1和下調IL-33表達水平。

Objective To observe the curative effect of mouse nerve growth factor and its influence on levels of BDNF, IGF-1, and IL-33 in patients with acute cerebral infarction.Methods Totally 106 cases of patients with acute cerebral infarction were chosen as the research objects between October 2015 and February 2017 in Fourth People’s Hospital of Langfang City. According to digital list method, the patients were randomly divided into treatment group and control group, 53 cases in each group. The patients in two groups were treated with conventional medicine of acute cerebral infarction, and the patients in treatment group were added to mNGF on the basis of conventional drugs, im injection, 18 μg each time, once daily. The patients in control group were not added to NGF treatment, and the patients in two groups were treated for 14 d. Before and after treatment, the degrees of neural function defect in two groups were scored according to NIH Stroke Scale (NIHSS), serum levels of brain-derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1) and interleukin-33 (IL-33) were determinated using enzyme-linked immunosorbent method.Results Compared with those before treatment, NIHSS scores decreased (P<0.05) after 14 d of treatment in two groups, but the reduced value in treatment group was obviously higher than that in control group (P<0.05). After treatment, the total effective rate (93.4%) of treatment group was better than that of control group (46.6%), and the difference was statistically significant (P<0.05). Compared with before treatment, serum levels of BDNF and IGF-1 rised (P<0.05), IL-33 decreased (P<0.05) after 14 d of treatment in two groups, but the changes in treatment group were significantly greater than those in control group (P<0.05).Conclusion mNGF can effectively reduce the severity of nervous functional defects, and effectively increase expression levels of BDNF and IGF 1 and decreasedexpression level of IL-33.

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