目的 分析脾氨肽口服凍干粉聯(lián)合阿奇霉素治療小兒肺炎支原體感染的療效及對免疫功能的影響。方法 以2013年5月—2016年6月開封市兒童醫(yī)院診治的肺炎支原體感染患兒106例為研究對象，根據(jù)入組的先后順序分為觀察組和對照組，每組53例。對照組患兒采用阿奇霉素序貫治療，觀察組在對照組的基礎(chǔ)上加用脾氨肽口服凍干粉，均治療3周。比較兩組的臨床療效、T細胞亞群（CD₄⁺、CD₈⁺、CD₄⁺/CD₈⁺）水平、細胞因子（IL-10、IL-17、TGF-β1）水平及安全性。結(jié)果 觀察組的臨床總有效率為94.39%，顯著高于對照組的79.25%，差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組的CD₄⁺、CD₄⁺/CD₈⁺較治療前顯著升高（P<0.05），且觀察組的顯著高于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）；CD₈⁺較治療前顯著降低（P<0.05），且觀察組的顯著低于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組的IL-10、IL-17、TGF-β1水平均較治療前顯著降低（P<0.05），且觀察組的顯著低于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）。兩組不良反應(yīng)發(fā)生率比較，差異無統(tǒng)計學(xué)意義。結(jié)論 脾氨肽口服凍干粉聯(lián)合阿奇霉素治療小兒肺炎支原體感染的臨床療效顯著，安全可靠，可顯著提高機體的細胞免疫功能，同時降低免疫損傷。

Objective To investigate the clinical effect of Spleen Aminopeptide Oral Lyophilized Powder on mycoplasma pneumonia in children and its influence in immune function.Methods Totally 103 cases of children infected with mycoplasma pneumonia from May 2013 to June 2016 were selected and divided into observation group and control group, with 53 cases in each group. The control group were treated with azithromycin, and observation group were treated with azithromycin combined with Spleen Aminopeptide Oral Lyophilized Powder. The clinical effect, T cell subgroup (CD₄⁺, CD₈⁺, CD₄⁺/CD₈⁺) levels, serum cytokine levels (IL-10, IL-17, TGF-β1) and safty were compared.Results The total effective rate of the observation group was 94.39%, which was significantly higher than that of the control group of 79.25% (P<0.05). After treatment, the levels of CD₄⁺, CD₄⁺/CD₈⁺ in two groups were significantly higher than those before treatment (P<0.05), and the levels of CD₄⁺, CD₄⁺/CD₈⁺ in observation were higher than those in control group significantly (P<0.05). The levels of CD₈⁺, IL-10, IL-17, TGF-β1 in two groups were significantly lower than before treatment (P<0.05), and those indexes in observation were lower than those in control group, the difference was statistically significant (P<0.05).Conclusion Azithromycin combined with Spleen Aminopeptide Oral Lyophilized Powder has remarkable clinical effect on mycoplasma pneumonia in children, which is cecurity and reliable, and can improve the cellular immune function and reduce the immune injury.