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[摘要]
目的 探討阿莫西林克拉維酸鉀分散片聯(lián)合注射用炎琥寧治療小兒肺炎的療效。方法 選取100例肺炎患兒,隨機(jī)分為兩組,對(duì)照組(48例)在常規(guī)治療基礎(chǔ)上給予注射用炎琥寧8 mg/kg,加入100 mL 5%葡萄糖注射液靜脈滴注,1 d/次;觀察組(52例)在對(duì)照組治療基礎(chǔ)之上,服用阿莫西林克拉維酸鉀片1片/次,2次/d,餐時(shí)服用。治療5~7 d。通過(guò)治療后的療效,咳嗽、肺部濕啰音消失時(shí)間、退熱時(shí)間、肺功能指標(biāo)及治療期間不良反應(yīng)情況,評(píng)價(jià)阿莫西林克拉維酸鉀分散片聯(lián)合注射用炎琥寧治療小兒肺炎的療效。結(jié)果 觀察組有效率92.3%,對(duì)照組有效率75.0%,觀察組的治療有效率高于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療后,觀察組患兒咳嗽、肺部濕啰音消失時(shí)間明顯短于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P<0.05);退熱時(shí)間與對(duì)照組相比,沒(méi)有顯著性差異。治療前,兩組FVC、FEV1和FEV1/FVC相比,差異無(wú)統(tǒng)計(jì)學(xué)意義;治療后兩組FVC、FEV1和FEV1/FVC均明顯升高,同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義(P<0.05),且觀察組上述肺功能指標(biāo)高于對(duì)照組,組間比較差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療期間,兩組不良反應(yīng)率無(wú)統(tǒng)計(jì)學(xué)差異。結(jié)論 阿莫西林克拉維酸鉀分散片聯(lián)合注射用炎琥寧治療小兒肺炎具有較好的治療效果,能顯著改善小兒肺炎癥狀,在抑制炎癥的同時(shí)提高患兒肺功能,用藥安全,值得臨床推廣使用。
[Key word]
[Abstract]
Objective To discuss the effect of Yanhuning Injection combined with amoxicillin and clavulanate potassium in treatment of infantile pneumonia.Methods Totally 100 infants with pneumonia were selected. They were randomly divided into two groups, the observation group (52 cases) were given Yanhuning Injection combined with amoxicillin and clavulanate potassium. The control group (48 cases) were given Yanhuning Injection. The effect of Yanhuning Injection combined with amoxicillin and clavulanate potassium in treatment of infantile pneumonia was evaluated using efficacy, cough, pulmonary rales disappeared time, pyretolysis time, pulmonary function indexes and adverse reaction during treatment as indexes.Results The effective rate was 92.3% in the observation group and 75.0% in the control group. The effective rate in the observation group was higher than that of the control group (P<0.05). The cough, pulmonary rales disappeared time of the observation group was shorter than that of the control group (P<0.05). There was no statistical significance on pyretolysis time between two groups. Before treatment, there was no statistical significance on FVC, FEV1 and FEV1/FVC% between two groups. After treatment, the FVC, FEV1 and FEV1/FVC% were increased and higher in the observation group (P<0.05). During treatment, there was no statistical significance on adverse reaction between two group.Conclusion Yanhuning Injection combined with amoxicillin and clavulanate potassium has a good effective on infantile pneumonia. It could improve the symptoms of pneumonia and lung function while inhibiting inflammation with good safety. It was worthy of clinical application.
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