2+超載和半胱天冬酶-3活化,保護神經(jīng)細(xì)胞和干細(xì)胞免遭凋亡性損傷;(2)抑制淀粉樣前體蛋白β位裂解酶-1的表達和β-分泌酶活性,阻滯內(nèi)源性傷害因子β-淀粉樣肽生成;(3)通過阻滯Notch信號通路,促進BMP信號通路,上調(diào)多種神經(jīng)營養(yǎng)因子表達,誘導(dǎo)間充質(zhì)干細(xì)胞和神經(jīng)干細(xì)胞定向分化成神經(jīng)元,提高許旺細(xì)胞增殖和功能,從而加速神經(jīng)修復(fù)、再生和功能恢復(fù)。;Some animal model experiments have found that salidroside has protective effect for injuries in various neurons and brain tissue induced by various causes, so it is expected to be used in the prevention and treatment of peripheral nerve injury, and cerebral ischemic and neurodegenerative diseases, such as cerebral infarction, Alzheimer’s disease, Parkinson’s disease, epilepsy, depression, Tourette syndrome, amyotrophic lateral sclerosis, and diabetic encephalopathy. Its mechanisms of neuroprotection are multiple: (1) Salidroside protects neurons and stem cells from apoptotic injury by antioxidation, blocking NOX2/ROS/MAPKs and REDD1/mTOR/p70S6K signaling pathways, and promoting AMPK/SIRT1, RhoA-MAPK and PI3K/Akt signaling pathways against various injurious factors-induced oxidative stress, inhibiting expression of inflammatory cytokines, preventing intracellular Ca2+ overload and caspase-3 activation; (2) Salidroside obstructs endogenous amyloid-β production by inhibition of expression of β-site amyloid precursor protein cleaving enzyme 1 and β-secretase activity. (3) Salidroside accelerates repair, regeneration and functional recovery of nerve by block Notch signaling pathway, and promoting BMP signaling pathway, super-regulating expression of neurotrophic factors, inducing neural stem cells and mesenchymal stem cells to differentiate into neural cells, and improving proliferation and function of Schwann cells."/>

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首頁 > 過刊瀏覽>2017年第40卷第7期 >2017,40(7):1019-1028. DOI:10.7501/j.issn.1674-6376.2017.07.028
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紅景天苷的神經(jīng)保護作用及作用機制研究進展

Research progress on neuroprotective effect and mechanism of salidroside

發(fā)布日期:2017-08-09
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