動(dòng)物實(shí)驗(yàn)結(jié)果顯示紅景天苷對(duì)多種原因引起的神經(jīng)細(xì)胞和腦組織損傷均有保護(hù)作用，有望用于周圍神經(jīng)損傷以及腦缺血性和神經(jīng)變性疾?。ㄈ缒X梗死、老年癡呆、帕金森病、癲癇、抑郁、抽動(dòng)穢語綜合征、肌萎縮性側(cè)索硬化癥和糖尿病腦病等）的防治。其神經(jīng)保護(hù)作用機(jī)制主要包括3個(gè)方面：（1）通過抗氧化作用，抑制NOX2/ROS/MAPKs和REDD1/mTOR/p70S6K信號(hào)通路，激活A(yù)MPK/SIRT1、RhoA-MAPK和PI3K/Akt信號(hào)通路，對(duì)抗各種損傷因子引起的氧化應(yīng)激，抑制炎性細(xì)胞因子表達(dá)，防止細(xì)胞內(nèi)Ca²⁺超載和半胱天冬酶-3活化，保護(hù)神經(jīng)細(xì)胞和干細(xì)胞免遭凋亡性損傷；（2）抑制淀粉樣前體蛋白β位裂解酶-1的表達(dá)和β-分泌酶活性，阻滯內(nèi)源性傷害因子β-淀粉樣肽生成；（3）通過阻滯Notch信號(hào)通路，促進(jìn)BMP信號(hào)通路，上調(diào)多種神經(jīng)營養(yǎng)因子表達(dá)，誘導(dǎo)間充質(zhì)干細(xì)胞和神經(jīng)干細(xì)胞定向分化成神經(jīng)元，提高許旺細(xì)胞增殖和功能，從而加速神經(jīng)修復(fù)、再生和功能恢復(fù)。

Some animal model experiments have found that salidroside has protective effect for injuries in various neurons and brain tissue induced by various causes, so it is expected to be used in the prevention and treatment of peripheral nerve injury, and cerebral ischemic and neurodegenerative diseases, such as cerebral infarction, Alzheimer’s disease, Parkinson’s disease, epilepsy, depression, Tourette syndrome, amyotrophic lateral sclerosis, and diabetic encephalopathy. Its mechanisms of neuroprotection are multiple: (1) Salidroside protects neurons and stem cells from apoptotic injury by antioxidation, blocking NOX2/ROS/MAPKs and REDD1/mTOR/p70S6K signaling pathways, and promoting AMPK/SIRT1, RhoA-MAPK and PI3K/Akt signaling pathways against various injurious factors-induced oxidative stress, inhibiting expression of inflammatory cytokines, preventing intracellular Ca²⁺ overload and caspase-3 activation; (2) Salidroside obstructs endogenous amyloid-β production by inhibition of expression of β-site amyloid precursor protein cleaving enzyme 1 and β-secretase activity. (3) Salidroside accelerates repair, regeneration and functional recovery of nerve by block Notch signaling pathway, and promoting BMP signaling pathway, super-regulating expression of neurotrophic factors, inducing neural stem cells and mesenchymal stem cells to differentiate into neural cells, and improving proliferation and function of Schwann cells.