3. Zebrafish models were treated with ANP by direct drug soaking at various concentrations. Results ANP had a significantly preventive effect on Zebrafish cerebral hemorrhage with an efficacy of 11%, 41%, and 48% at concentrations of 27.8, 83.3, and 250 μg/mL, respectively, and the incidence of cerebral hemorrhage in 83.3 and 250 g/mL groups decreased significantly compared with model group (P<0.001). Compared with model group, the red cell staining intensity of Zebrafish in 333 and 1 000 g/mL groups increased significantly (P<0.001), and the thrombus prevention rates of 111, 333, and 1000 g/mL groups were 5%, 33%, and 64% respectively. Compared with model group, the intestinal vascular area of Zebrafish in ANP 11.1, 33.3, and 100.0 μg/mL groups increased significantly (P<0.001), and the rate of angiogenesis was 21%, 25% and 26% respectively. ANP promoted dyskinesia recovery by 48%, 88%, and 78%, and improved response efficiency by 15%, 82% and 75%, respectively in AD zebrafish at concentrations of 111, 333, and 1000 μg/mL. Conclusions Our results in this study support ANP as a preventive and therapeutic medicine for cerebral hemorrhage, cerebral ischemia, thrombosis and AD."/>

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首頁(yè) > 過(guò)刊瀏覽>2017年第40卷第8期 >2017,40(8):1067-1072. DOI:10.7501/j.issn.1674-6376.2017.08.005
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安宮牛黃丸防治腦血管疾病作用研究

Therapeutic effects of Angong Niuhuang Pills on cerebrovascular diseases in Zebrafish models

發(fā)布日期:2017-08-09
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