目的 建立用電感耦合等離子體發(fā)射光譜法（ICP-OES）測定右旋糖酐鐵中鉛、鎘、砷、汞、鈷、釩、硒、鉬8種重金屬元素含量的分析方法。方法 通過檢測波長考察，儀器參數(shù)優(yōu)化，驗證基體效應(yīng)干擾，考察內(nèi)標(biāo)物校正干擾，測定8種重金屬元素的含量。結(jié)果 內(nèi)標(biāo)法校正基體效應(yīng)干擾，待測元素回收率由83%~90%提高為94%~100%，方法準(zhǔn)確度良好，加標(biāo)回收率在94.3%~101.5%，方法精密度良好（RSD<3.5%，n=6）。各待測元素線性關(guān)系良好，相關(guān)系數(shù)均大于0.999，檢出限為0.22~8.54 ng/mL，定量限為0.68~25.73 ng/mL。結(jié)論 方法準(zhǔn)確度高、靈敏度高、迅速可靠，可用于右旋糖酐鐵中8種重金屬元素含量的測定。

Objective To establish a method for the determination of 8 heavy metal elements of Pb, Cd, As, Hg, Co, V, Se, Mo in iron dextran by inductively coupled plasma optical emission spectrometry (ICP-OES). Method Through selection of detection wavelengths, optimization of instrument parameters, verification of matrix effect interference and investigation of internal standard for correction of matrix effect interference, the 8 heavy metal elements were analyzed by ICP-OES. Results The recovery rate of the detected elements were increased from 83%-90% to 94%-100%, after correction of matrix effect interference by internal standard method. The accuracy of the method were good. The spiked recoveries of the detected elements were from 94.3% to 101.5%. The precision of the method were good (RSD<3.5%, n=6). The linearities of the detected elements were good, and the correlation coefficients were all greater than 0.999. The detection limits were from 0.22 to 8.54 ng/mL. The quantization limits were from 0.68 to 25.73 ng/mL. Conclusion The established method was accurate, sensitivity, rapid and reliable, which can be applied to the determination of contents of 8 heavy metal elements in iron dextran.