目的 探討六味地黃丸聯合二甲雙胍治療2型糖尿病腎陰虧虛的療效。方法 選取120例2型糖尿病腎陰虧虛患者，隨機分為兩組，對照組（60例）口服二甲雙胍片0.5 g/次，3次/d，觀察組在對照組治療基礎上，口服六味地黃丸大蜜丸1丸/次，2次/d。療程均為4周。觀察并記錄兩組臨床療效，治療前后空腹血糖、餐后2 h血糖水平、治療前后總癥狀積分以及治療期間不良反應情況，以此評價六味地黃丸聯合二甲雙胍治療2型糖尿病腎陰虧虛的療效。結果 觀察組治療有效率為88.3%，明顯高于對照組的65.0%，差異有統(tǒng)計學意義（P<0.05）。治療前兩組患者空腹血糖和餐后2 h血糖水平相比，無統(tǒng)計學差異；治療后兩組空腹血糖和餐后2 h血糖水平均下降，組內差異有統(tǒng)計學意義（P<0.05）；且觀察組空腹血糖、餐后2 h血糖均低于對照組，組間差異有統(tǒng)計學意義（P<0.05）。治療前，兩組癥狀積分相比無統(tǒng)計學差異；治療后兩組總癥狀積分明顯下降，組內差異有統(tǒng)計學意義（P<0.05）；且觀察組總癥狀積分低于對照組，組間差異有統(tǒng)計學意義（P<0.05）。治療期間，對照組1例低血糖反應，觀察組1例低血糖反應，1例輕度惡心，兩組不良反應相比，無統(tǒng)計學差異。結論 六味地黃丸聯合二甲雙胍對2型糖尿病具有較好的治療效果，能明顯改善糖尿病的臨床癥狀，降糖作用明顯，藥品安全性高，值得臨床推廣使用。

Objective To discuss the efficacy of six ingredient rehmannia pill combined with metformin in treatment of type 2 diabetes with Qi-Yin deficiency. Methods 120 cases with type 2 diabetes were selected. They were divided into two groups randomly. The observation group (60 cases) took six ingredient rehmannia pill combined with metformin. The control group (60 cases) took metformin. The efficacy of interlocking intramedullary nail and fracture contusion capsule in treatment of open tibial fracutre was evaluated by fasting blood glucose, postprandial 2 h blood glucose, total symptom scores before and after treatment, adverse reaction during treatment. Results The effective rate of observation group was significantly higher than that of the control group (P<0.05). Before treatment, fasting blood glucose and postprandial 2 h blood glucose level had no significant difference between two groups. After treatment, the blood glucose of two groups were decreased (P<0.05). The fasting blood glucose and blood glucose 2 h after meal of observation group were lower than that of the control group (P<0.05). Before treatment, total symptom scores had no significant difference. After treatment, the two groups of the total symptom scores were decreased significantly (P<0.05), and the observation group the total symptom score lower than that of the control group (P<0.05). During the treatment, the control group of 1 cases of hypoglycemia, the observation group of 1 cases of hypoglycemia, 1 cases of mild nausea. The adverse reactions of two groups had no significant difference. Conclusion Six ingredient rehmannia pill combined with metformin had good effect on type 2 diabetes. It could significantly improve the symptoms of diabetes diagnosed by traditional Chinese medicine. The hypoglycemic effect was obvious with high drugy safety. It was worthy of clinical application.