目的 探討舒血寧注射液治療急性胰腺炎的臨床療效及其對氧化應(yīng)激反應(yīng)的影響。方法 選擇2013年12月-2016年11月在駐馬店市中醫(yī)院進行治療的急性胰腺炎患者150例，隨機分為兩組，對照組65例患者，接受常規(guī)治療，觀察組85例患者，在對照組基礎(chǔ)上接受舒血寧注射液治療，每天1次，兩組患者均連續(xù)治療20 d。評價并比較兩組患者治療的臨床療效，分別檢測兩組患者治療前后的炎癥因子及氧化應(yīng)激因子的含量并比較分析；通過APACHEⅡ以及BISAP評分量表評價兩組患者治療前后的胰腺損傷程度。結(jié)果 觀察組的總有效率為91.8%，顯著高于對照組的80.0%，差異有統(tǒng)計學(xué)意義（P<0.05）。經(jīng)治療后，兩組患者腫瘤壞死因子-α（TNF-α）、白介素-6（IL-6）以及丙二醛（MDA）較治療前均顯著降低，組內(nèi)比較差異有統(tǒng)計學(xué)意義（P<0.05）；且觀察組顯著低于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）。兩組患者超氧化物歧化酶（SOD）較治療前顯著升高，差異有統(tǒng)計學(xué)意義（P<0.05）；且觀察組明顯高于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）。兩組患者經(jīng)治療后APACHEⅡ以及BISAP評分較治療前均顯著降低，差異有統(tǒng)計學(xué)意義（P<0.05）；且觀察組顯著低于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 舒血寧注射液用于治療急性胰腺炎可顯著降低機體的炎性以及氧化應(yīng)激反應(yīng)，提高臨床療效，值得臨床推廣應(yīng)用。

Objective To explore the curative effect of Shuxuening injection for patients with acute pancreatitis and which influence on the oxidative stress. Methods 150 patients with acute pancreatitis were enrolled in our hospital from December 2013 to November 2016, of which patients divided into two groups randomly, control group (n=65) accepted conventional therapy, and study group (n=85) adopted Shuxuening injection based on the treatment of control group. The curative effect of two groups were evaluated, and the factors of inflammatory and oxidative stress response were detected responsibly before and after treatment, the pancreatic injury degree were evaluated via the gauge of APACHEⅡ and BISAP. Results The total effective rate of study group for curative effect was higher significantly than those patients in control group (P<0.05); After treatment, the tumor necrosis factor α (TNF-α), interleukin -6 (IL-6) and malondialdehyde (MDA) of two groups decreased significantly compared with before treatment (P<0.05), and the level of which factors in study group were lower than those control group, and which difference was significance (P<0.05), the superoxide dismutase (SOD) of all patients increased significantly compared with before treatment (P<0.05), and SOD level of patients in study group was higher than those patients in control group (P<0.05); the APACHEⅡ and BISAP score of all patients went down remarkably compared with before treatment (P<0.05), and which score of patients in study group was lower than that control group, and which difference was significance (P<0.05). Conclusions Shuxuening Injection for patients with acute pancreatitis deserved popularization in clinic, which not only decreased the inflammatory and oxidative stress response significantly, but also increased the curative effect remarkably.