疫苗的免疫接種是預(yù)防傳染病的最有效方法之一。近年以來隨著生物技術(shù)迅猛發(fā)展，B群腦膜炎球菌疫苗的研究也取得了突破性發(fā)展，應(yīng)用反向疫苗學(xué)技術(shù)開發(fā)的新型B群腦膜炎球菌疫苗已陸續(xù)被歐洲醫(yī)藥管理局和美國食品和藥品管理局批準(zhǔn)上市。盡管目前國內(nèi)尚未批準(zhǔn)相關(guān)產(chǎn)品上市，但一些企業(yè)和研究院所已在加緊研發(fā)。為了進(jìn)一步了解B群腦膜炎球菌疫苗，推動國內(nèi)B群腦膜炎球菌疫苗的研發(fā)，綜述不同類型B群腦膜炎球菌疫苗的研究現(xiàn)狀及其面臨的挑戰(zhàn)。

It is generally accepted that vaccinations are one of the most effective tool for control of infectious diseases. In recent years, the research on meningococcal group B vaccines has made progress extensively. A new meningococcal group B vaccine, developed by the reverse vaccinology technology, has been approved by the European Medicines Agency and the Food and Drug Administration. Although no related products has been approve till now in China, some meningococcal group B vaccines are also developing in domestic companies and research institutes. Therefore, to further understand these vaccines and facilitate the development of meningococcal group B vaccines, this paper reviews advance and challenge in research on meningococcal group B vaccines.

國家重大新藥創(chuàng)制項目（2013ZX09304101）