侵襲與轉(zhuǎn)移為惡性腫瘤的重要生物學(xué)特征，也是臨床腫瘤治療失敗和高死亡率的重要原因，尋找安全有效的抗腫瘤轉(zhuǎn)移藥物已成為轉(zhuǎn)化醫(yī)學(xué)的一項(xiàng)迫切任務(wù)。中藥單體成分姜黃素、貝母乙素、β-欖香烯等以其療效確切、毒副作用小等優(yōu)勢(shì)，成為近年來(lái)抗腫瘤轉(zhuǎn)移藥物研究和開發(fā)的熱點(diǎn)。綜述了近年來(lái)中藥單體成分抗腫瘤侵襲轉(zhuǎn)移的研究進(jìn)展。

As the essential characteristics of malignant cancer, invasion and metastasis are the main reason for failure treatment and high death rate of cancer patients. It is necessary to find out safe and effective anti-invasion and anti-metastasis drugs for the improvement of clinical efficacy. With the definite therapeutic effect and mild side-effects, Chinese materia medica(CMM) including curcumin, peiminine, β-elemi and so on, have become hotspots in anti-invasion and anti-metastasis drugs research. The mechanisms for the effective ingredients of CMM anti-tumor invasion and metastasis were reviewed in this paper.

中國(guó)博士后科學(xué)基金面上項(xiàng)目（2016M591398）；天津醫(yī)科大學(xué)基本科研業(yè)務(wù)費(fèi)資助項(xiàng)目（2016YD07）；天津醫(yī)科大學(xué)科學(xué)基金青年項(xiàng)目（2015KYZQ13）