固體分散體作為一種制劑的中間體，在改善難溶性藥物的溶出與提高其生物利用度方面發(fā)揮了重要的作用。固體分散技術(shù)是提高難溶性藥物的溶出與溶解度最具應(yīng)用潛力的新技術(shù)之一，其發(fā)展將推動(dòng)制劑領(lǐng)域日臻完善。重點(diǎn)從固體分散體的載體材料、各種新型制備技術(shù)及其比較、固體分散劑型的應(yīng)用與穩(wěn)定性問(wèn)題4個(gè)方面展開(kāi)介紹，闡述了影響固體分散體穩(wěn)定性的因素，并提出了防止其老化的有效措施，最后對(duì)固體分散技術(shù)的發(fā)展提出了中肯的建議。

Solid dispersions (SD) as a preparation of intermediates have played an important role in improving the dissolution of insoluble drugs and its bioavailability. SD technique is one of the most promising techniques to improve the dissolution and solubility of insoluble drugs, and the development of SD technique will promote the gradual perfection in preparative field. This review focuses on the carrier materials of SD, various new preparation techniques and their comparisons, application of solid dispersion formulations, and stability problems of SD. The factors influencing the stability of SD are described, and the effective measures to prevent the aging of SD are put forward. Finally, the review puts forward the practical suggestions of the solid dispersion technique.