近年來(lái)，對(duì)體內(nèi)藥物轉(zhuǎn)運(yùn)體的研究取得了重大進(jìn)展，越來(lái)越多的轉(zhuǎn)運(yùn)體被發(fā)現(xiàn)及研究，其對(duì)藥物的跨膜轉(zhuǎn)運(yùn)，具有重要的意義。各種轉(zhuǎn)運(yùn)體包括攝取轉(zhuǎn)運(yùn)體和外排轉(zhuǎn)運(yùn)體對(duì)藥物的體內(nèi)過(guò)程以及藥物相互作用均有著重要影響。研究表明大多數(shù)抗生素的體內(nèi)過(guò)程都與轉(zhuǎn)運(yùn)體和代謝酶有關(guān)，因此，歸納總結(jié)了轉(zhuǎn)運(yùn)體和代謝酶在抗生素的藥動(dòng)學(xué)和藥物相互作用中的最新研究進(jìn)展，為臨床合理用藥提供參考。

In recent years, the research on drug transporters has made great progress, more and more transporters have been found and studied, and they have shown important roles in the transport of drug across the cellular membrane. Various transporters, including uptake transporters and efflux transporters, have important effects on the pharmacokinetics and drug-drug interactions. Studies have shown that the process in vivo of most of the antibiotics was related to transporters and metabolizing enzymes (cytochrome P450 and CYP450). Therefore, this article summarized the latest research progress in pharmacokinetics and drug-drug interactions of transporters and CYP450, so that provides evidence for clinical rational use of antibiotics.

國(guó)家自然科學(xué)基金項(xiàng)目（81473280）