肝臟是機(jī)體重要的代謝和解毒器官。肝細(xì)胞膜上存在多種功能性膜蛋白即肝臟藥物轉(zhuǎn)運(yùn)體，它的功能是介導(dǎo)許多內(nèi)源性及外源性物質(zhì)如藥物攝取進(jìn)入肝臟，在肝臟內(nèi)經(jīng)過一定的代謝轉(zhuǎn)化，最終將其從肝臟排入膽汁。研究發(fā)現(xiàn)，轉(zhuǎn)運(yùn)體和代謝酶在化學(xué)性肝損傷的發(fā)展過程中發(fā)揮重要的作用，其涉及的多種調(diào)控機(jī)制成為研究熱點(diǎn)。就肝臟轉(zhuǎn)運(yùn)體和代謝酶的分類、轉(zhuǎn)運(yùn)體和代謝酶在化學(xué)性肝損傷中的變化及其調(diào)控機(jī)制作一綜述。

Liver is an important metabolic and detoxification organ in the body. Hepatic transporters are a series of functional membrane proteins that are extensively expressed in the liver. They are responsible for the uptake of endogenous and exogenous substances such as medicines into hepatocytes and excretion of their metabolic products into bile. Recent studies have provided that transporters and metabolic enzymes play important roles in the chemical substances-induced liver injury, and its various regulatory mechanisms have become hot topics of research. In this paper, we summarize the classification of hepatic transporters and metabolic enzymes and the changes of transporters and metabolic enzymes in the chemical substances-induced liver injury and its regulatory mechanism.

國家自然科學(xué)基金項目（81473280）