膽汁淤積性肝損傷是臨床常見(jiàn)的肝臟疾病，主要由體內(nèi)膽汁酸平衡失調(diào)引起，其發(fā)病機(jī)制與膽汁酸轉(zhuǎn)運(yùn)體、合成酶和代謝酶的表達(dá)和功能變化直接相關(guān)。核受體通過(guò)調(diào)控膽汁酸轉(zhuǎn)運(yùn)體及代謝酶的表達(dá)，在膽汁淤積所致的肝損傷中發(fā)揮重要作用。對(duì)肝臟轉(zhuǎn)運(yùn)體和代謝酶在膽汁淤積性肝損傷中的作用及核受體對(duì)轉(zhuǎn)運(yùn)體和代謝酶的調(diào)控機(jī)制作一綜述。

Cholestatic liver injury, which is mainly caused by the disruption of bile acids, is common in the clinic. The pathogenesis of cholestatic liver injury is directly related to the changes of bile acid-related transporters, synthetic and metabolic enzymes. Nuclear receptors play a crucial part in cholestatic liver injury by regulating the expression of transporters and metabolic enzymes that maintaining the homeostasis of bile acids. In this review, we focus on the role of hepatic transporters and metabolic enzymes in cholestatic liver injury and the mechanism of nuclear receptors on the regulation of transporters and metabolic enzymes.

國(guó)家自然科學(xué)基金項(xiàng)目（81302826，81473280）；遼寧省重點(diǎn)實(shí)驗(yàn)室項(xiàng)目（LZ2015027）