轉(zhuǎn)運(yùn)體是細(xì)胞膜上的功能性蛋白，在腎臟中表達(dá)廣泛，對(duì)許多內(nèi)源性或外源性物質(zhì)的腎臟分泌及重吸收起到了至關(guān)重要的作用。許多藥物（包括有機(jī)陰離子藥物、有機(jī)陽離子藥物及肽類藥物等）在腎臟排泄的過程中，經(jīng)主要集中在近端腎小管的轉(zhuǎn)運(yùn)體主動(dòng)轉(zhuǎn)運(yùn)介導(dǎo)。臨床合用某些藥物時(shí)可能在腎臟發(fā)生轉(zhuǎn)運(yùn)體介導(dǎo)的相互作用。從腎臟主要轉(zhuǎn)運(yùn)體的分布及功能出發(fā)，綜述其在藥物腎臟排泄中的作用。

Transporters are a class of functional membrane proteins which are broadly expressed in the kidney and play a vital role in the reabsorption and secretion of many endogenous and xenobiotic compounds by the kidney. The renal proximal tubule is the primary site of transporter-mediated active transport for many drugs, including organic anion drugs, organic cation drugs and peptide drugs. Transporter-mediated drug-drug interactions may occur in the kidney when some drugs are co-administration. In this review, we focus on the location and function of major transporters in the kidney and summarize their vital role in renal drug elimination.

國(guó)家自然科學(xué)基金項(xiàng)目（81473280）