轉運體是細胞膜上的功能性蛋白，在腎臟中表達廣泛，對許多內源性或外源性物質的腎臟分泌及重吸收起到了至關重要的作用。許多藥物（包括有機陰離子藥物、有機陽離子藥物及肽類藥物等）在腎臟排泄的過程中，經(jīng)主要集中在近端腎小管的轉運體主動轉運介導。臨床合用某些藥物時可能在腎臟發(fā)生轉運體介導的相互作用。從腎臟主要轉運體的分布及功能出發(fā)，綜述其在藥物腎臟排泄中的作用。

Transporters are a class of functional membrane proteins which are broadly expressed in the kidney and play a vital role in the reabsorption and secretion of many endogenous and xenobiotic compounds by the kidney. The renal proximal tubule is the primary site of transporter-mediated active transport for many drugs, including organic anion drugs, organic cation drugs and peptide drugs. Transporter-mediated drug-drug interactions may occur in the kidney when some drugs are co-administration. In this review, we focus on the location and function of major transporters in the kidney and summarize their vital role in renal drug elimination.

國家自然科學基金項目（81473280）