藥物轉(zhuǎn)運體在體內(nèi)藥物吸收、分布和排泄過程中發(fā)揮著重要的作用。轉(zhuǎn)運體在各組織器官的分布和表達受到表觀遺傳修飾調(diào)控，導(dǎo)致某些藥物體內(nèi)處置過程出現(xiàn)明顯的個體差異。隨著表觀遺傳學(xué)的發(fā)展，基于表觀遺傳修飾（如DNA甲基化、組蛋白修飾、microRNA干預(yù)等）調(diào)控藥物轉(zhuǎn)運體的相關(guān)研究越來越多。對表觀遺傳調(diào)控藥物轉(zhuǎn)運體研究進行綜述。

Drug transporters play a key role in drug absorption, distribution and excretion. The distribution and expression of transporters in tissues and organs are regulated by epigenetic modifications, resulting in individual differences of drugs disposition significantly. With the development of epigenetics, researches on the regulation of drug transporters expression based on epigenetic modifications (DNA methylation, histone modification, microRNA interference, etc.) have been more and more reported. In this paper, we will summarize the epigenetic modifications regulating drug transporters.