目的 評價右旋布洛芬注射液對動物中樞神經(jīng)系統(tǒng)、心血管系統(tǒng)及呼吸系統(tǒng)的影響。方法 通過小鼠自主活動試驗、運動協(xié)調(diào)試驗和戊巴比妥鈉催眠/睡眠試驗，考察右旋布洛芬注射液對中樞神經(jīng)系統(tǒng)的影響；通過對清醒Beagle犬遙測心電圖、血壓和呼吸指標的檢測，考察右旋布洛芬注射液對心血管系統(tǒng)和呼吸系統(tǒng)的影響。結(jié)果 右旋布洛芬注射液20、40、80 mg/kg劑量時對小鼠自主活動、爬桿行為均無顯著影響，劑量為80 mg/kg時與戊巴比妥鈉誘導的小鼠催眠/睡眠具有協(xié)同作用；劑量為10、20、40 mg/kg時對Beagle犬中樞神經(jīng)系統(tǒng)、心血管系統(tǒng)和呼吸系統(tǒng)均沒有顯著影響。相同劑量條件下，右旋布洛芬注射液與布洛芬注射液比較，不良反應未見增加。結(jié)論 右旋布洛芬注射液對自主活動、運動協(xié)調(diào)能力、心血管系統(tǒng)和呼吸系統(tǒng)沒有顯著影響，大劑量時與戊巴比妥鈉誘導小鼠催眠/睡眠有協(xié)同作用。

Objective To study the effects of Dexibuprofen injection on the central nervous, cardiovascular and respiratory systems in animals. Methods The effect of Dexibuprofen injection on central nervous system was observed by autonomic activities experiment, mice concordant ability experiment and hypnotize experiment induced by pentobarbital. The effects of Dexibuprofen injection on circulatory system and respiratory system were observed by measuring the implanted telemetry system, blood pressure, ECG, respiratory rate and tidal volume of Beagle's dogs. Results Dexibuprofen injection (80 mg/kg) showed synergistic action with pentobarbital, and no significant effects on autonomic activities and concordant ability at doses of 20, 40 and 80 mg/kg in mice. Dexibuprofen injection at doses of 10, 20 and 40 mg/kg had no effect on the central nervous, cardiovascular and respiratory systems. In the same dose, the adverse reaction of Dexibuprofen injection was not increased compared with Ibuprofen injection. Conclusion Dexibuprofen injection (mice 40 mg/kg, dog 40 mg/kg) has none toxicity on cardiovascular, respiratory and central nervous systems, but at the dose of 80 mg/kg in mice has obvious effect on central nervous system.

山東省自主創(chuàng)新及成果轉(zhuǎn)化專項基金資助項目（2014ZZCX02104）