目的 研究不同種類(lèi)藥用輔料成分對(duì)麥角甾苷固體脂質(zhì)納米粒（SLN）理化性質(zhì)的影響，為研究SLN的處方篩選提供依據(jù)。方法 采用乳化-固化法制備麥角甾苷-SLN，單一變量法考察山崳酸甘油酯（Compritol ATO 888）、單硬脂酸甘油酯、大豆卵磷脂、Myrj52等輔料對(duì)麥角甾苷-SLN粒徑、包封率、表征分散度（PDI）等理化性質(zhì)的影響，采用透射電鏡法觀察麥角甾苷-SLN的形態(tài)，X-射線衍射（XRD）分析其藥物晶體結(jié)構(gòu)。結(jié)果 隨Compritol ATO 888用量增加，麥角甾苷-SLN粒徑不斷減小，包封率逐漸減小，PDI逐漸增加；隨單硬脂酸甘油酯的用量增加，粒徑明顯增大，包封率略有降低，PDI減?。浑S卵磷脂用量增加，粒徑明顯增大，包封率降低，PDI減小；隨Myrj52用量明顯增加，粒徑減小，包封率增加，PDI增大；麥角甾苷-SLN外觀圓整，呈球形；麥角甾苷以分子分散狀態(tài)被包裹在SLN中。結(jié)論 不同輔料對(duì)麥角甾苷-SLN的理化性質(zhì)均產(chǎn)生一定影響趨勢(shì)，為制備SLN的處方篩選研究提供啟示與思路。

Objective To explore the impacts of different excipients on physical and chemical properties of Acteoside solid lipid nanoparticles (Acteoside-SLN), and make experimental evidence for the study of prescription SLN. Methods Emulsification-evaporation was appropriate for the preparation of Acteoside-SLN. Single variable method was used for fumbling the effects of Compritol 888 ATO, glyceryl monostearate, soy lecithin, Myrj52 and other accessories on the physicochemical properties including nanoparticles particle size, encapsulation efficiency and characterization dispersity (PDI) of Acteoside-SLN. Transmission electron microscope was used to observe the morphology of Acteoside-SLN and the structure of Acteoside in SLN was measured by XRD. Results With the increasing of the amount of Compritol 888 ATO, the particle size of nanoparticles decreased significantly, encapsulation efficiency decreased slightly, PDI increased; With the increasing of amount of glycerol monostearate, particle size increased obviously, encapsulation efficiency decreased slightly, and PDI decreased; With the increasing of the amount of lecithin, particles size increased significantly, encapsulation efficiency decreased, and PDI decreased; With the increasing of Myrj52 amount, the nanoparticles particle size decreased, encapsulation rate and PDI increased slightly. The appearance of Acteoside-SLN was presented uniform spherically. Acteoside was wrapped in SLN in a molecular dispersion state. Conclusion Various additives have a greater impact on physicochemical properties of Acteoside-SLN, and inspiration for prescription screening of SLN is supplied by this study.