目的 比較鹽酸米諾環(huán)素聯(lián)合甲硝唑或替硝唑治療慢性牙周炎的療效及安全性。方法 選取2014年2月-2016年2月于西安市第九醫(yī)院進行治療的慢性牙周炎患者260例作為研究對象，采用隨機數(shù)字表法將其分為觀察組與對照組各130例。對照組患者使用鹽酸米諾環(huán)素聯(lián)合甲硝唑治療，觀察組患者使用鹽酸米諾環(huán)素聯(lián)合替硝唑治療，療程均為4周。對比兩組患者臨床療效、牙周各項指標以及不良反應。結果 觀察組治療總有效率為94.62%，明顯高于對照組的83.85%，差異有統(tǒng)計學意義（P<0.05）。治療后，兩組患者牙周各指標均較治療前明顯改善，其中觀察組各指標均優(yōu)于對照組，差異有統(tǒng)計學意義（P<0.05）。治療期間，觀察組不良反應發(fā)生率為8.46%，對照組為14.62%，兩組差異不顯著。觀察組復發(fā)率為1.54%，對照組為6.92%，兩組差異不顯著。結論 鹽酸米諾環(huán)素聯(lián)合替硝唑治療慢性牙周炎療效高于鹽酸米諾環(huán)素聯(lián)合甲硝唑治療，安全性高，值得臨床推廣。

Objective To compare the clinical effect and safety of minocycline hydrochloride combined with metronidazole or tinidazole in treatment of chronic periodontitis. Methods Patients with chronic periodonitis (260 cases) accepted in Ninth Hospital of Xi'an from February 2014 to February 2016 were randomly divided into observation group and control group with 130 cases in each group. Patients in control group were given minocycline hydrochloride combined with metronidazole, and patients in observation group were given minocycline hydrochloride combined with tinidazole. Then the clinical effect, periodontal indexes and adverse reactions of two groups were compared. Results The total effective rate of observation group was 94.62%, which was obviously higher than that of control group (83.85%, P<0.05). The periodontal indexes of observation group were higher than control group (P<0.05). The adverse reaction rate of observation group was 8.46%, that of control group was 14.62%, which had no differences. The recurrence rate of observation group was 1.54%, that of control group was 6.92%, which had no differences. Conclusion Using minocycline hydrochloride combined with tinidazole has better effect in treatment of chronic periodontitis, which is safety and worthy of clinical application.