目的 探討右美托咪定聯(lián)合七氟烷對(duì)小兒眼科手術(shù)術(shù)后鎮(zhèn)靜的影響。方法 選擇2014年1月-2016年8月在安康市中醫(yī)醫(yī)院進(jìn)行眼科手術(shù)的患兒200例，將其隨機(jī)分為兩組，每組100例，A組患兒接受七氟烷聯(lián)合生理鹽水術(shù)后鎮(zhèn)靜，B組患兒接受七氟烷聯(lián)合右美托咪定術(shù)后鎮(zhèn)靜，比較兩組患兒的手術(shù)情況以及術(shù)后VAS疼痛評(píng)分、Ramsay鎮(zhèn)靜評(píng)分以及PAED躁動(dòng)評(píng)分，記錄兩組患兒術(shù)后不良反應(yīng)的發(fā)生情況并進(jìn)行統(tǒng)計(jì)學(xué)分析。結(jié)果 兩組患兒的手術(shù)時(shí)間差異不顯著，B組患兒術(shù)后清醒較A組晚，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。B組患兒術(shù)后拔管質(zhì)量評(píng)分低于A組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且B組術(shù)后使用鎮(zhèn)痛劑的患兒明顯較A組少，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。T1、T2及T3時(shí)刻，B組患兒的VAS評(píng)分顯著小于A組患兒，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；T1及T2時(shí)B組患兒的Ramsay評(píng)分顯著高于A組患兒，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；B組患兒PAED評(píng)分明顯低于A組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。B組患兒術(shù)后惡心嘔吐、呼吸抑制、術(shù)后躁動(dòng)的發(fā)生率顯著低于A組患兒，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且B組患兒術(shù)后發(fā)生不良反應(yīng)的總發(fā)生率顯著低于A組患兒，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 右美托咪定聯(lián)合七氟烷用于小兒眼科手術(shù)術(shù)后鎮(zhèn)靜的臨床療效顯著且安全性較好，可以顯著緩解患兒蘇醒期的躁動(dòng)程度，降低患兒術(shù)后發(fā)生不良反應(yīng)的發(fā)生率，值得臨床推廣應(yīng)用。

Objective To explore the effect of dexmedetomidine combined with sevoflurane on the postoperative sedation for children undergoing ophthalmic operation. Methods Pediatric patients (200 cases) in Ankang Hospital of Traditional Chinese Medicine from January 2014 to August 2016 were enrolled, of which patients were divided into two groups randomly, Group A (n=100) accepted sevoflurane combined with normal saline, and Group B (n=100) adopted sevoflurane combined with dexmedetomidine. The operative conditions and postoperative VAS, Ramsay and PEAD scores were evaluated, and the postoperative adverse reactions were recorded and analyzed. Results There was no significance of the operation time between two groups, the wakened time of Group B was later than that of Group A significantly (P<0.05), the postoperative extubation quality score of Group B was lower than that in Group A (P<0.05), and the times of using analgesic in Group B was fewer than that of Group A (P<0.05); The VAS score of patients in Group B was significantly lower than that of Group A at the time points of T1, T2 and T3; At the time points of T1 and T2, the Ramsay score of patients in Group B was higher than that in Group A, and PAED score of Group B was lower than that in Group A, with significant difference between Groups A and B (P<0.05); The incidence of nausea and vomiting, respiratory depression, postoperative agitation of patients in Group B was lower significantly than that of Group A, and the incidence of total adverse reactions in Group B was also lower than that in Group A significantly (P<0.05). Conclusion The clinical efficacy and safety of dexmedetomidine combined with sevoflurane for patients undergoing ophthalmic operation are remarkable and deserve popularization in clinic, which not only relieves the restlessness agitation of patients in recovery period, but also decreases the incidence of adverse reactions.