目的 研究注射用鼠神經(jīng)生長因子聯(lián)合甲潑尼龍治療急性脊髓損傷的臨床效果。方法 選擇2013年5月-2017年5月在銅川市人民醫(yī)院進(jìn)行診治的急性脊髓損傷患者60例，隨機(jī)分為兩組。兩組均采取內(nèi)固定術(shù)、椎管減壓術(shù)、止血、抗炎以及脫水等常規(guī)治療。對照組靜脈滴注甲潑尼龍30 mg/kg，持續(xù)15 min后，再按照每小時5.4 mg/kg的劑量進(jìn)行連續(xù)靜脈滴注23 h，觀察組聯(lián)合肌內(nèi)注射鼠神經(jīng)生長因子進(jìn)行治療，每次30 μg，每天1次，兩組均治療2個月。比較兩組的臨床治療效果，治療前后的運(yùn)動功能和感覺功能評分，獨(dú)立性生活能力和日常生活能力評分，以及不良反應(yīng)發(fā)生情況。結(jié)果 觀察組的有效率為80.00%（24/30），明顯高于對照組的63.33%（19/30），差異有統(tǒng)計學(xué)意義（P<0.05）。兩組治療后的運(yùn)動功能以及感覺功能評分均明顯升高，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；且觀察組明顯高于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）。兩組治療后的獨(dú)立性生活能力以及日常生活能力評分均明顯升高，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；且觀察組明顯高于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）。觀察組的藥物不良反應(yīng)發(fā)生率為16.67%（5/30），與對照組的20.00%（6/30）相比無明顯差異。結(jié)論 注射用鼠神經(jīng)生長因子聯(lián)合甲潑尼龍治療急性脊髓損傷的臨床效果明顯優(yōu)于單獨(dú)采用大劑量甲潑尼龍沖擊治療，可以有效改善患者的神經(jīng)功能，提高生活能力，且安全性較高。

Objective To investigate clinical observation of methylprednisolone combined with mouse nerve growth factor for injection on treating acute spinal cord injury. Methods From May 2013 to May 2017, 60 patients with acute spinal cord injury in our hospital were selected and randomly divided into two groups. The two groups were all treated by conventional therapy including internal fixation, spinal canal decompression, hemostasis, anti-inflammation, dehydration and so on. The methylprednisolone was intravenous instilled into control group with 30 mg/kg for 15 min, and then it was intravenous in stilled continuously for 23 h according to dosage of 5.4 mg/kg per hour. The treatment both intravenous instillation of methylprednisolone and intramuscular injection of mouse nerve growth factor with 30 μg per time and 1 time per day were applied in the observation group. The two groups were all treated for two months. Clinical therapeutic efficacy was compared in the two groups. The indexes, such as motor and sensory function, independent living and daily living ability, occurrence of adverse reactions, were scored before and after the treatment. Results The effective rate in observation group 80.00% (24/30) was higher dramatically than that in control group 63.33% (19/30) (P < 0.05). After treatment, the score of motor and sensory function, independent living and daily living ability both in two groups were all increased significantly (P < 0.05), and the increase in observation group was more obvious than that in control group (P < 0.05). The incidence of adverse reactions had no significant difference between that in observation group 16.67% (5/30)) and control group 20.00% (6/30). Conclusion Clinical efficacy of methylprednisolone combined with mouse nerve growth factor for injection on treating acute spinal cord injury is obviously superior to use a massive dose of methylprednisolone pulse therapy alone. The treatment of methylprednisolone combined with mouse nerve growth factor for injection can improve effectively neurological function of patients and increase living ability, and having high security.