目的 觀察臨床應(yīng)用特利加壓素聯(lián)合生長(zhǎng)抑素治療肝硬化失代償期并急性上消化道大出血的療效。方法 選取2014年1月-2016年6月在上海交通大學(xué)醫(yī)學(xué)院附屬第九人民醫(yī)院進(jìn)行治療的69例肝硬化失代償期并急性上消化道大出血患者，按隨機(jī)數(shù)字表法分為對(duì)照組33例和觀察組36例，對(duì)照組患者給予生長(zhǎng)抑素治療，觀察組在對(duì)照組治療基礎(chǔ)上聯(lián)合應(yīng)用特利加壓素治療，兩組患者均以治療1周為1療程。對(duì)比分析兩組患者止血效果及不良反應(yīng)發(fā)生情況，并觀察記錄兩組患者輸血量、止血時(shí)間、住院時(shí)間、大便隱血轉(zhuǎn)陰時(shí)間以及血壓和尿量恢復(fù)時(shí)間。結(jié)果 兩組患者治療后止血效果比較，觀察組總有效率為94.4%，明顯高于對(duì)照組的75.8%，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。兩組患者治療后輸血量、止血時(shí)間、住院時(shí)間、大便隱血轉(zhuǎn)陰時(shí)間以及血壓和尿量恢復(fù)時(shí)間比較，觀察組均明顯低于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后兩組患者不良反應(yīng)發(fā)生率及病死率比較均無明顯差異。結(jié)論 臨床應(yīng)用特利加壓素聯(lián)合生長(zhǎng)抑素治療肝硬化失代償期并急性上消化道大出血止血效果顯著，可有效改善預(yù)后，且安全性高，可在臨床推廣應(yīng)用。

Objective The efficacy of tripsin combined with growth inhibition in treatment of decompensated liver cirrhosis combined with upper gastrointestinal bleeding. Methods 69 cases decompensated liver cirrhosis combined with upper gastrointestinal bleeding from Jan. 2014 to June 2016 in our hospital were chosen and divided into the control group and observation group. The control group were given inhibition, the observation group were given inhibition, the efficacy of two groups were compared. Results The hemostatic effect total efficacy of two groups after treatment of observation group were obvious higher than control group (P < 0.05). The blood transfusions amount, bleeding duration, the inpatient time, the defecate revulating time, blood pressure and urinary recovery time of observation group were shorter than control group (P < 0.05). The adverse reaction rate and case fatality rate of two groups had no significant difference. Conclusion The tripsin combined with inhibition in treatment of decompensated liver cirrhosis combined with upper gastrointestinal bleeding had great efficacy and safety, which could improve prognosis, be worth of clinical promotion.