目的 探討硝苯地平聯(lián)合硫酸鎂在妊高癥（PIH）患者中的治療效果以及對患者血清同型半胱氨酸（Hcy）和C反應(yīng)蛋白（CRP）水平的影響。方法 將宿遷市中醫(yī)院自2013年6月-2015年12月間收治的PIH患者66例作為研究對象，隨機(jī)分為研究組和對照組各33例，對照組患者僅給予硫酸鎂進(jìn)行治療，研究組患者在使用硫酸鎂的基礎(chǔ)上聯(lián)合使用硝苯地平，觀察兩組患者的臨床療效，并分別使用循環(huán)酶法和免疫比濁法測定兩組患者治療前后血清Hcy和CRP水平變化情況。結(jié)果 治療后，兩組患者收縮壓（SBP）和舒張壓DBP均降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療后研究組水平低于對照組水平，差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療前兩組患者的Hcy和CRP水平均顯著高于正常孕婦，且隨著PIH的分級增高顯著增高，差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；治療后兩組患者Hcy和CRP水平均明顯降低，和治療前比較差異顯著（P<0.05）；其中研究組患者降低程度優(yōu)于對照組，重度患者組間比較差異顯著（P<0.05）。結(jié)論 硝苯地平聯(lián)合硫酸鎂治療妊高癥患者臨床效果顯著，患者Hcy和CRP水平改善情況優(yōu)于單獨(dú)使用硫酸鎂治療，可在臨床范圍內(nèi)推廣使用。

Objective To investigate the therapeutic effect of nifedipine in patients with PIH and its effect on serum homocysteine (Hcy) and C-reactive protein (CRP) levels in patients. Methods 66 patients with PIH from June 2013 to December 2015 were randomly divided into study group and control group (33 cases). The study group was treated with magnesium sulfate on the basis of the combination of magnesium sulfate The patients were treated with nifedipine and the control group was treated with nifedipine only. The clinical efficacy of the two groups was observed. The changes of serum Hcy and CRP levels were measured by circulating enzyme method and immunoturbidimetry before and after treatment. Results SBP and DBP were decreased in both groups after treatment, and the level of the study group was lower than that of the control group (P < 0.05). The levels of Hcy and CRP were significantly higher in the two groups before treatment (P < 0.05). After treatment, the levels of Hcy and CRP in the two groups were significantly lower than those before treatment, and the patients in the study group were significantly lower than those in the control group (P < 0.05), and the difference was statistically significant (P < 0.05).There is no significant difference between the two groups (P < 0.05). Conclusion Nifedipine combined with magnesium sulfate is more effective in the treatment of patients with pregnancy induced hypertension. The improvement of Hcy and CRP levels in patients is better than that in the control group, which can be used in the clinical scope.