目的 探討貝那普利與纈沙坦單用或聯(lián)用對老年糖尿病腎病（DN）患者的療效。方法 入選60例老年DN患者，隨機分為3組，分別為貝那普利組、纈沙坦組及聯(lián)合組，其中貝那普利組（20例）予貝那普利10 mg/d，纈沙坦組（20例）予纈沙坦80 mg/d，聯(lián)合組（20例）予貝那普利10 mg/d聯(lián)合纈沙坦80 mg/d。比較3組治療前后平均動脈壓（MAP）、血脂、常用腎功能指標、尿白蛋白排出量（UAE）、尿轉化生長因子β（TGF-β）水平變化及不良反應。結果 治療后，3組血脂水平均無明顯變化，MAP明顯降低，同組治療前后比較差異有統(tǒng)計學意義（P<0.05），但組間比較無明顯差異。治療后，3組血肌酐（Scr）均明顯降低，同組治療前后比較差異有統(tǒng)計學意義（P<0.05）；且聯(lián)合組明顯低于貝那普利組和纈沙坦組，差異有統(tǒng)計學意義（P<0.05）。治療后，貝那普利組和纈沙坦組血尿酸（UA）無明顯變化，聯(lián)合組UA明顯降低，同組治療前后比較差異有統(tǒng)計學意義（P<0.05），且明顯低于貝那普利組和纈沙坦組，差異有統(tǒng)計學意義（P<0.05）。治療后，3組血尿素氮（BUN）均明顯降低，同組治療前后比較差異有統(tǒng)計學意義（P<0.05），但組間比較無明顯差異。治療后，3組UAE、TGF-β均明顯降低，同組治療前后比較差異有統(tǒng)計學意義（P<0.05）；且聯(lián)合組明顯低于貝那普利組和纈沙坦組，差異有統(tǒng)計學意義（P<0.05）。組間不良反應無明顯差異。結論 貝那普利聯(lián)合纈沙坦治療老年DN的療效明顯優(yōu)于兩藥單用，對血壓、腎功能的改善作用更顯著。

Objective To investigate the effect of Benazepril Hydrochloride Tablets and Valsartan alone or in combination on elderly patients with diabetic nephropathy. Methods 60 elderly patients with DN were selected, 20 cases were given Benazepril Hydrochloride Tablets 10 mg/d, 20 cases were given Valsartan 80 mg/d and the other 20 cases were given Benazepril Hydrochloride Tablets 10 mg/d combination Valsartan 80 mg/d, as Benazepril group, valsartan group and combination group. The mean arterial pressure (MAP), blood lipid, renal function, urinary albumin excretion (UAE), urinary transforming growth factor beta (TGF-β) levels and adverse reactions were compared in the three groups before and after treatment. Results After treatment, there were no significant change in serum lipid levels between the three groups, and MAP decreased significantly (P < 0.05), but there were no significant difference between the groups; the serum creatinine (Scr) of the three groups were significantly lower (P < 0.05), and of the combination group was significantly lower than that of the Benazepril group and the valsartan group (P < 0.05); the serum uric acid (UA) of the Benazepril group and the valsartan group were no significant change, while of the combination group were decreased significantly (P < 0.05), and was significantly lower than that of the Benazepril group and the valsartan group (P < 0.05); the serum urea nitrogen (BUN) of the three groups were decreased significantly (P < 0.05), but there were no significant difference between the groups; the UAE and TGF-β of the three groups were decreased significantly (P < 0.05), and of the combination group were significantly lower than those of the Benazepril group and the valsartan group (P < 0.05). Conclusion Benazepril Hydrochloride Tablets combined with valsartan in the treatment of elderly patients with DN was better than their single, which improve the effect on blood pressure and renal function more significantly.